ID   1.14.13.98
DE   Cholesterol 24-hydroxylase.
AN   Cholesterol 24-monooxygenase.
AN   Cholesterol 24S-hydroxylase.
AN   Cytochrome P450 46A1.
CA   Cholesterol + NADPH + O(2) = (24S)-24-hydroxycholesterol + NADP(+) +
CA   H(2)O.
CF   Heme-thiolate.
CC   -!- Can also produce 25-hydroxycholesterol.
CC   -!- In addition, it can further hydroxylate the product to 24,25-
CC       dihydroxycholesterol and 24,27-dihydroxycholesterol.
CC   -!- This reaction is the first step in the enzymatic degradation of
CC       cholesterol in the brain as hydroxycholesterol can pass the blood-
CC       brain barrier whereas cholesterol cannot.
PR   PROSITE; PDOC00081;
DR   Q9Y6A2, CP46A_HUMAN;  Q9WVK8, CP46A_MOUSE;
//