ENZYME entry: EC 1.14.13.99

Accepted Name
24-hydroxycholesterol 7-alpha-hydroxylase.
Alternative Name(s)
24-hydroxycholesterol 7-alpha-monooxygenase.
Reaction catalysed
(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) <=> (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Found in liver microsomes and in ciliary non-pigmented epithelium.
  • Specific for (24R)-cholest-5-ene-3-beta,24-diol as substrate.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.99
EC2PDB1.14.13.99
ExplorEnz1.14.13.99
PRIAM enzyme-specific profiles1.14.13.99
KEGG Ligand Database for Enzyme Nomenclature1.14.13.99
IUBMB Enzyme Nomenclature1.14.13.99
IntEnz1.14.13.99
MEDLINEFind literature relating to 1.14.13.99
MetaCyc1.14.13.99
UniProtKB/Swiss-Prot
Q9NYL5, CP39A_HUMAN;  Q9JKJ9, CP39A_MOUSE;  

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