ID 1.14.14.105 DE taxane 10beta-hydroxylase. AN 5-alpha-taxadienol-10-beta-hydroxylase. AN CYP725A1. CA taxa-4(20),11-dien-5alpha-yl acetate + reduced [NADPH--hemoprotein CA reductase] + O2 = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + CA oxidized [NADPH--hemoprotein reductase] + H2O + H(+). CC -!- This microsomal cytochrome-P450 (heme-thiolate) enzyme from the plant CC Taxus cuspidata is involved in the biosynthesis of the diterpenoid CC antineoplastic drug taxol (paclitaxel). CC -!- Formerly EC 1.14.13.76. DR Q9AXM6, T10H_TAXCU ; //