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ENZYME

ENZYME entry: EC 1.14.14.106

Accepted Name
taxane 13alpha-hydroxylase
Alternative Name(s)
CYP725A2
Reaction catalysed
O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol
Comment(s)
  • This cytochrome-P450(heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
  • Formerly EC 1.14.13.77.
Cross-references
BRENDA1.14.14.106
EC2PDB1.14.14.106
ExplorEnz1.14.14.106
PRIAM enzyme-specific profiles1.14.14.106
KEGG Ligand Database for Enzyme Nomenclature1.14.14.106
IUBMB Enzyme Nomenclature1.14.14.106
IntEnz1.14.14.106
MEDLINEFind literature relating to 1.14.14.106
MetaCyc1.14.14.106
Rhea expert-curated reactions1.14.14.106
UniProtKB/Swiss-Prot
Q8W4T9, T13H_TAXCU

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