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ENZYME

ENZYME entry: EC 1.14.14.116

Accepted Name
averantin hydroxylase
Alternative Name(s)
AVN hydroxylase
CYP60A1
Reaction catalysed
  • (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]
  • (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein isolated from the saprophytic mold Aspergillus parasiticus.
  • Involved in aflatoxin biosynthesis.
  • Does not react with (1'R)-averantin.
  • Formerly EC 1.14.13.174.
Cross-references
BRENDA1.14.14.116
EC2PDB1.14.14.116
ExplorEnz1.14.14.116
PRIAM enzyme-specific profiles1.14.14.116
KEGG Ligand Database for Enzyme Nomenclature1.14.14.116
IUBMB Enzyme Nomenclature1.14.14.116
IntEnz1.14.14.116
MEDLINEFind literature relating to 1.14.14.116
MetaCyc1.14.14.116
Rhea expert-curated reactions1.14.14.116
UniProtKB/Swiss-Prot
Q12732, AFLG_ASPPUM2YJD1, AVNA_DOTSN

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