ENZYME entry: EC 1.14.14.14

Accepted Name
Aromatase.
Alternative Name(s)
CYP19A1.
Estrogen synthetase.
Reaction catalysed
  • Testosterone + 3 O(2) + 3 reduced flavoproteins <=> 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins
  • Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins <=> estrone + formate + 4 H(2)O + 3 oxidized flavoproteins
Comment(s)
The enzyme catalyzes three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17-beta- estradiol, respectively.
Cross-references
BRENDA1.14.14.14
EC2PDB1.14.14.14
ExplorEnz1.14.14.14
PRIAM enzyme-specific profiles1.14.14.14
KEGG Ligand Database for Enzyme Nomenclature1.14.14.14
IUBMB Enzyme Nomenclature1.14.14.14
IntEnz1.14.14.14
MEDLINEFind literature relating to 1.14.14.14
MetaCyc1.14.14.14
UniProtKB/Swiss-Prot
O42145, C19AA_DANRE;  P79690, CP191_CARAU;  Q29624, CP191_PIG;  
O73686, CP192_CARAU;  P79430, CP192_PIG;  P79304, CP193_PIG;  
Q6QHT9, CP19A_ANGJA;  P46194, CP19A_BOVIN;  Q95M61, CP19A_CALJA;  
Q5QQX7, CP19A_CANLF;  Q6YI21, CP19A_CAPHI;  P19098, CP19A_CHICK;  
P79699, CP19A_COTJA;  O46512, CP19A_HORSE;  P11511, CP19A_HUMAN;  
Q92111, CP19A_ICTPU;  Q69FB6, CP19A_LAGAC;  P28649, CP19A_MOUSE;  
P70091, CP19A_ORENI;  Q92087, CP19A_ORYLA;  Q29605, CP19A_RABIT;  
P22443, CP19A_RAT;  Q9XS28, CP19A_SHEEP;  Q92112, CP19A_TAEGU;  

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