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ENZYME

ENZYME entry: EC 1.14.14.149

Accepted Name
5-epiaristolochene 1,3-dihydroxylase
Alternative Name(s)
5-epi-aristolochene 1,3-dihydroxylase
CYP71D20
EAH
Reaction catalysed
(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Kinetic studies suggest that 1beta-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3.
  • However the reverse order via 3alpha-hydroxyepiaristolochene does occur.
  • Formerly EC 1.14.13.119.
Cross-references
BRENDA1.14.14.149
EC2PDB1.14.14.149
ExplorEnz1.14.14.149
PRIAM enzyme-specific profiles1.14.14.149
KEGG Ligand Database for Enzyme Nomenclature1.14.14.149
IUBMB Enzyme Nomenclature1.14.14.149
IntEnz1.14.14.149
MEDLINEFind literature relating to 1.14.14.149
MetaCyc1.14.14.149
Rhea expert-curated reactions1.14.14.149
UniProtKB/Swiss-Prot
Q94FM7, C71DK_TOBAC

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