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ENZYME

ENZYME entry: EC 1.14.14.151

Accepted Name
premnaspirodiene oxygenase
Alternative Name(s)
CYP71D55
HPO
Hyoscymus muticus premnaspirodiene oxygenase
Reaction catalysed
(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone.
  • 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2beta-hydroxy derivatives that are not oxidized further.
  • Formerly EC 1.14.13.121.
Cross-references
BRENDA1.14.14.151
EC2PDB1.14.14.151
ExplorEnz1.14.14.151
PRIAM enzyme-specific profiles1.14.14.151
KEGG Ligand Database for Enzyme Nomenclature1.14.14.151
IUBMB Enzyme Nomenclature1.14.14.151
IntEnz1.14.14.151
MEDLINEFind literature relating to 1.14.14.151
MetaCyc1.14.14.151
Rhea expert-curated reactions1.14.14.151
UniProtKB/Swiss-Prot
A6YIH8, C7D55_HYOMU

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