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ENZYME

ENZYME entry: EC 1.14.14.161

Accepted Name
nepetalactol monooxygenase
Alternative Name(s)
CYP76A26
iridoid oxidase
Reaction catalysed
(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P450 (heme thiolate) protein.
  • It catalyzes three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
Cross-references
BRENDA1.14.14.161
EC2PDB1.14.14.161
ExplorEnz1.14.14.161
PRIAM enzyme-specific profiles1.14.14.161
KEGG Ligand Database for Enzyme Nomenclature1.14.14.161
IUBMB Enzyme Nomenclature1.14.14.161
IntEnz1.14.14.161
MEDLINEFind literature relating to 1.14.14.161
MetaCyc1.14.14.161
Rhea expert-curated reactions1.14.14.161
UniProtKB/Swiss-Prot
W8JIS5, IO_CATRO

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