ENZYME entry: EC 1.14.14.168

Accepted Name

germacreene A acid 8beta-hydroxylase

Alternative Name(s)

CYP71BL1

CYP71BL6

Reaction catalysed

germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Comment(s)

A cytochrome P450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower).
The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12- oate to inunolide (12,8beta) does not seem to occur spontaneously.
The enzyme from Inula hupehensis also forms some 8alpha- hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170).

Cross-references

BRENDA

1.14.14.168

EC2PDB

1.14.14.168

ExplorEnz

1.14.14.168

PRIAM enzyme-specific profiles

1.14.14.168

KEGG Ligand Database for Enzyme Nomenclature

1.14.14.168

IUBMB Enzyme Nomenclature

1.14.14.168

IntEnz

1.14.14.168

MEDLINE

Find literature relating to 1.14.14.168

MetaCyc

1.14.14.168

Rhea expert-curated reactions

1.14.14.168

UniProtKB/Swiss-Prot

F8S1H3, C7BL1_HELAN

A0A2H4DGV8, C7BL6_INUHU

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