| Accepted Name |
|---|
| 3,5,6-trichloropyridin-2-ol monooxygenase
|
| Reaction catalysed |
|---|
- 3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
- 3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
- 6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O
|
| Comment(s) |
|---|
- The enzyme, characterized from a number of bacterial species,
participates in the degradation of 3,5,6-trichloropyridin-2-ol (TCP),
a metabolite of the common organophosphorus insecticide chlorpyrifos.
- The enzyme is a multifunctional flavin-dependent monooxygenase that
displaces three chlorine atoms by attacking three different positions
in the substrate.
- Each reaction catalyzed by the enzyme displaces a single chlorine and
results in formation of a dione, which must be reduced by FADH2
before the monooxygenase could catalyze the next step.
- The large amount of FADH2 that is required is generated by a
dedicated flavin reductase (TcpX). cf. EC 1.14.14.173.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.172 |
| EC2PDB | 1.14.14.172 |
| ExplorEnz | 1.14.14.172 |
| PRIAM enzyme-specific profiles | 1.14.14.172 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.172 |
| IUBMB Enzyme Nomenclature | 1.14.14.172 |
| IntEnz | 1.14.14.172 |
| MEDLINE | Find literature relating to 1.14.14.172 |
| MetaCyc | 1.14.14.172 |
| Rhea expert-curated reactions | 1.14.14.172 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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