Expasy logo

ENZYME

ENZYME entry: EC 1.14.14.177

Accepted Name
ultra-long-chain fatty acid omega-hydroxylase
Alternative Name(s)
CYP4F22
Reaction catalysed
an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • The enzyme, which is expressed in the epidermis of mammals, catalyzes the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36).
  • The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.
Cross-references
BRENDA1.14.14.177
EC2PDB1.14.14.177
ExplorEnz1.14.14.177
PRIAM enzyme-specific profiles1.14.14.177
KEGG Ligand Database for Enzyme Nomenclature1.14.14.177
IUBMB Enzyme Nomenclature1.14.14.177
IntEnz1.14.14.177
MEDLINEFind literature relating to 1.14.14.177
MetaCyc1.14.14.177
Rhea expert-curated reactions1.14.14.177
UniProtKB/Swiss-Prot
Q6NT55, CP4FN_HUMAN

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-