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ENZYME

ENZYME entry: EC 1.14.14.184

Accepted Name
5-dehydro-6-demethoxyfumagillol synthase
Alternative Name(s)
Fma-P450
fumagillin multifunctional cytochrome P450 monooxygenase
Reaction catalysed
(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
Comment(s)
The enzyme, characterized from the mold Aspergillus fumigatus, catalyzes a complex transformation comprising hydroxylation, bicyclic ring-opening, and two epoxidations, generating the sesquiterpenoid core skeleton of fumagillin.
Cross-references
BRENDA1.14.14.184
EC2PDB1.14.14.184
ExplorEnz1.14.14.184
PRIAM enzyme-specific profiles1.14.14.184
KEGG Ligand Database for Enzyme Nomenclature1.14.14.184
IUBMB Enzyme Nomenclature1.14.14.184
IntEnz1.14.14.184
MEDLINEFind literature relating to 1.14.14.184
MetaCyc1.14.14.184
Rhea expert-curated reactions1.14.14.184
UniProtKB/Swiss-Prot
Q4WAZ6, FMAG_ASPFU

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