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ENZYME entry: EC 1.14.14.32

Accepted Name
17-alpha-hydroxyprogesterone deacetylase.
Alternative Name(s)
17-alpha-hydroxyprogesterone 17,20-lyase.
17-alpha-hydroxyprogesterone acetaldehyde-lyase.
CYP17.
CYP17A1.
Reaction catalysed
  • 17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O(2) <=> androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • 17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O(2) <=> 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A microsomal protein that catalyzes two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3-beta- hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis.
  • The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome.
  • The enzymes from different organisms differ in their substrate specificity; while the enzymes from pig, hamster, and rat accept both 17-alpha-hydroxyprogesterone and 17-alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter.
  • Formerly EC 4.1.2.30.
Cross-references
BRENDA1.14.14.32
EC2PDB1.14.14.32
ExplorEnz1.14.14.32
PRIAM enzyme-specific profiles1.14.14.32
KEGG Ligand Database for Enzyme Nomenclature1.14.14.32
IUBMB Enzyme Nomenclature1.14.14.32
IntEnz1.14.14.32
MEDLINEFind literature relating to 1.14.14.32
MetaCyc1.14.14.32
UniProtKB/Swiss-Prot
Q9GMC7, CP17A_BISBI;  P05185, CP17A_BOVIN;  Q9N0U7, CP17A_CAPHI;  
Q64410, CP17A_CAVPO;  P12394, CP17A_CHICK;  Q9GMC8, CP17A_FELCA;  
Q95328, CP17A_HORSE;  P05093, CP17A_HUMAN;  O73853, CP17A_ICTPU;  
Q2XVA1, CP17A_MACFA;  Q8HYM9, CP17A_MACMU;  P70687, CP17A_MESAU;  
P27786, CP17A_MOUSE;  P30437, CP17A_ONCMY;  P70085, CP17A_ORYLA;  
Q8HYN1, CP17A_PANTR;  Q8HYN0, CP17A_PAPCY;  Q9GLD2, CP17A_PAPHU;  
Q91Z85, CP17A_PERLE;  P19100, CP17A_PIG;  O57525, CP17A_RANDY;  
P11715, CP17A_RAT;  Q29497, CP17A_SHEEP;  Q92113, CP17A_SQUAC;  

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