ID   1.14.14.50
DE   tabersonine 3-oxygenase.
AN   CYP71D1V2.
AN   T3O.
CA   (1) 16-methoxytabersonine + reduced [NADPH--hemoprotein reductase] + O2 =
CA   (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + oxidized
CA   [NADPH--hemoprotein reductase] + H2O + H(+).
CA   (2) (-)-tabersonine + reduced [NADPH--hemoprotein reductase] + O2 = (3R)-
CA   1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + oxidized [NADPH-
CA   -hemoprotein reductase] + H2O + H(+).
CC   -!- This cytochrome P450 enzyme acts on 16-methoxytabersonine, leading to
CC       biosynthesis of vindoline in the plant Catharanthus roseus
CC       (Madagascar periwinkle).
CC   -!- It can also act on tabersonine, resulting in the production of small
CC       amounts of vindorosine.
CC   -!- The products are unstable and, in the absence of EC 1.1.99.41 will
CC       convert into 3-epoxylated compounds.
DR   I1TEM1, T3O_CATRO  ;
//