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ENZYME

ENZYME entry: EC 1.14.14.89

Accepted Name
4'-methoxyisoflavone 2'-hydroxylase
Alternative Name(s)
CYP81E1
CYP81E3
CYP81E7
isoflavone 2'-hydroxylase
isoflavone 2'-monooxygenase
Reaction catalysed
formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A.
  • Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
  • EC 1.14.14.90 is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.
  • Formerly EC 1.14.13.53.
Cross-references
BRENDA1.14.14.89
EC2PDB1.14.14.89
ExplorEnz1.14.14.89
PRIAM enzyme-specific profiles1.14.14.89
KEGG Ligand Database for Enzyme Nomenclature1.14.14.89
IUBMB Enzyme Nomenclature1.14.14.89
IntEnz1.14.14.89
MEDLINEFind literature relating to 1.14.14.89
MetaCyc1.14.14.89
Rhea expert-curated reactions1.14.14.89
UniProtKB/Swiss-Prot
Q6WNR0, C81E7_MEDTR

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