ENZYME entry: EC 1.14.15.12

Accepted Name
Pimeloyl-[acyl-carrier protein] synthase.
Alternative Name(s)
CYP107H1.
Reaction catalysed
A long-chain acyl-[acyl-carrier protein] + 2 reduced flavodoxin + 3 O(2) <=> pimeloyl-[acyl-carrier protein] + an n-alkanal + 2 oxidized flavodoxin + 3 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme catalyzes an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl- [acyl-carrier protein], an intermediate in the biosynthesis of biotin.
  • The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal.
  • The mechanism is similar to EC 1.14.15.6, followed by a hydroxylation step, which may occur spontaneously.
Cross-references
BRENDA1.14.15.12
EC2PDB1.14.15.12
ExplorEnz1.14.15.12
PRIAM enzyme-specific profiles1.14.15.12
KEGG Ligand Database for Enzyme Nomenclature1.14.15.12
IUBMB Enzyme Nomenclature1.14.15.12
IntEnz1.14.15.12
MEDLINEFind literature relating to 1.14.15.12
MetaCyc1.14.15.12
UniProtKB/Swiss-Prot
P53554, BIOI_BACSU

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-