ENZYME entry: EC 1.14.15.36

Accepted Name

sterol 14alpha-demethylase (ferredoxin)

Alternative Name(s)

CYP51

Reaction catalysed

a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]

Comment(s)

A cytochrome P450 (heme-thiolate) protein found in several bacterial species.
The enzyme, which is involved in sterol biosynthesis, catalyzes a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker. cf. EC 1.14.14.154.

Cross-references

BRENDA

1.14.15.36

EC2PDB

1.14.15.36

ExplorEnz

1.14.15.36

PRIAM enzyme-specific profiles

1.14.15.36

KEGG Ligand Database for Enzyme Nomenclature

1.14.15.36

IUBMB Enzyme Nomenclature

1.14.15.36

IntEnz

1.14.15.36

MEDLINE

Find literature relating to 1.14.15.36

MetaCyc

1.14.15.36

Rhea expert-curated reactions

1.14.15.36

UniProtKB/Swiss-Prot

P0A513, CP51_MYCBO	P9WPP8, CP51_MYCTO	P9WPP9, CP51_MYCTU
Q5IZM4, CP51_MYCVP

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-