ID   1.14.16.4
DE   tryptophan 5-monooxygenase.
AN   indoleacetic acid-5-hydroxylase.
AN   L-tryptophan hydroxylase.
AN   tryptophan 5-hydroxylase.
AN   tryptophan hydroxylase.
CA   (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 =
CA   (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-
CA   tryptophan.
CC   -!- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein
CC       kinase.
CC   -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
CC       dihydrobiopterin, both spontaneously and by the action of
CC       EC 4.2.1.96.
CC   -!- The 6,7-dihydrobiopterin can be enzymically reduced back to
CC       tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
CC       more stable compound 7,8-dihydrobiopterin.
DR   P90925, PH4H_CAEEL ;  Q54XS1, PH4H_DICDI ;  P17276, PH4H_DROME ;
DR   P70080, TPH1_CHICK ;  P17752, TPH1_HUMAN ;  P17532, TPH1_MOUSE ;
DR   P17290, TPH1_RABIT ;  P09810, TPH1_RAT   ;  Q92142, TPH1_XENLA ;
DR   Q0EAB8, TPH2_HORSE ;  Q8IWU9, TPH2_HUMAN ;  Q2HZ26, TPH2_MACMU ;
DR   Q8CGV2, TPH2_MOUSE ;  Q8CGU9, TPH2_RAT   ;
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