ID   1.14.16.4
DE   Tryptophan 5-monooxygenase.
AN   Indoleacetic acid-5-hydroxylase.
AN   L-tryptophan hydroxylase.
AN   Tryptophan 5-hydroxylase.
AN   Tryptophan hydroxylase.
CA   L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan +
CA   4a-hydroxytetrahydrobiopterin.
CF   Iron.
CC   -!- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein
CC       kinase.
CC   -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
CC       dihydrobiopterin, both spontaneously and by the action of
CC       EC 4.2.1.96.
CC   -!- The 6,7-dihydrobiopterin can be enzymically reduced back to
CC       tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
CC       more stable compound 7,8-dihydrobiopterin.
PR   PROSITE; PDOC00316;
DR   Q54XS1, PH4H_DICDI ;  P17276, PH4H_DROME ;  P70080, TPH1_CHICK ;
DR   P17752, TPH1_HUMAN ;  P17532, TPH1_MOUSE ;  P17290, TPH1_RABIT ;
DR   P09810, TPH1_RAT   ;  Q0EAB8, TPH2_HORSE ;  Q8IWU9, TPH2_HUMAN ;
DR   Q2HZ26, TPH2_MACMU ;  Q8CGV2, TPH2_MOUSE ;  Q8CGU9, TPH2_RAT   ;
DR   Q92142, TPH_XENLA  ;
//