ID   1.14.16.7
DE   phenylalanine 3-monooxygenase.
AN   phenylalanine 3-hydroxylase.
CA   (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 =
CA   (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-
CA   phenylalanine.
CC   -!- The enzyme, characterized from the bacterium Streptomyces
CC       coeruleorubidus, forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine),
CC       which is one of the building blocks in the biosynthesis of the uridyl
CC       peptide antibiotics pacidamycins.
CC   -!- The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-
CC       dihydropteridine, both spontaneously and by the action of
CC       EC 4.2.1.96.
CC   -!- The 6,7-dihydropteridine must be enzymically reduced back to
CC       tetrahydropteridine, by EC 1.5.1.34, before it slowly rearranges into
CC       the more stable but inactive compound 7,8-dihydropteridine.
DR   F5BFC8, PH3H_STRC4 ;
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