ID   1.14.17.3
DE   peptidylglycine monooxygenase.
AN   PAM.
AN   peptidyl alpha-amidating enzyme.
AN   peptidylglycine 2-hydroxylase.
AN   peptidylglycine alpha-amidating monooxygenase.
CA   a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-
CA   terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical.
CC   -!- A copper protein.
CC   -!- The enzyme binds two copper ions with distinct roles during
CC       catalysis.
CC   -!- Peptidylglycines with a neutral amino acid residue in the penultimate
CC       position are the best substrates for the enzyme.
CC   -!- The product is unstable and dismutates to glyoxylate and the
CC       corresponding desglycine peptide amide, a reaction catalyzed by
CC       EC 4.3.2.5.
CC   -!- In mammals, the two activities are part of a bifunctional protein.
CC   -!- Involved in the final step of biosynthesis of alpha-melanotropin and
CC       related biologically active peptides.
DR   P08478, AMDA_XENLA ;  P12890, AMDB_XENLA ;  P83388, AMDL_CAEEL ;
DR   P10731, AMD_BOVIN  ;  P19021, AMD_HUMAN  ;  P97467, AMD_MOUSE  ;
DR   P14925, AMD_RAT    ;  Q95XM2, PHM_CAEEL  ;  O01404, PHM_DROME  ;
//