ENZYME entry: EC 1.14.18.2
| Accepted Name |
|---|
| CMP-N-acetylneuraminate monooxygenase.
|
| Alternative Name(s) |
|---|
| CMP-N-acetylneuraminate hydroxylase. |
| CMP-N-acetylneuraminic acid hydroxylase. |
| CMP-Neu5Ac hydroxylase. |
| Cytidine monophosphoacetylneuraminate monooxygenase. |
| Reaction catalysed |
|---|
| CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H(2)O |
| Cofactor(s) |
|---|
| Iron; Iron-sulfur.
|
| Comment(s) |
|---|
- The ferricytochrome b5 produced is reduced by NADH and EC 1.6.2.2.
- The enzyme can be activated by Fe(2+) or Fe(3+).
- Formerly EC 1.14.13.45 and EC 1.14.99.18.
|
| Cross-references |
|---|
| BRENDA | 1.14.18.2 |
| EC2PDB | 1.14.18.2 |
| ExplorEnz | 1.14.18.2 |
| PRIAM enzyme-specific profiles | 1.14.18.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.18.2 |
| IUBMB Enzyme Nomenclature | 1.14.18.2 |
| IntEnz | 1.14.18.2 |
| MEDLINE | Find literature relating to 1.14.18.2 |
| MetaCyc | 1.14.18.2 |
| UniProtKB/Swiss-Prot |
| Q95V11, CMAH_ASTRU; | Q9WV23, CMAH_CRIGR; | Q6GML1, CMAH_DANRE; |
| Q8MJC8, CMAH_GORGO; | Q9TUJ2, CMAH_MACMU; | Q61419, CMAH_MOUSE; |
| Q8MJD0, CMAH_PANPA; | O97598, CMAH_PANTR; | O19074, CMAH_PIG; |
| Q8MJC6, CMAH_PONPY; | Q8AVF5, CMAH_XENLA; |
|
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