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ENZYME entry: EC 1.14.18.2

Accepted Name
CMP-N-acetylneuraminate monooxygenase.
Alternative Name(s)
CMP-N-acetylneuraminate hydroxylase.
CMP-N-acetylneuraminic acid hydroxylase.
CMP-Neu5Ac hydroxylase.
Cytidine monophosphoacetylneuraminate monooxygenase.
Reaction catalysed
CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H(2)O
Cofactor(s)
Iron; Iron-sulfur.
Comment(s)
  • The ferricytochrome b5 produced is reduced by NADH and EC 1.6.2.2.
  • The enzyme can be activated by Fe(2+) or Fe(3+).
  • Formerly EC 1.14.13.45 and EC 1.14.99.18.
Cross-references
BRENDA1.14.18.2
EC2PDB1.14.18.2
ExplorEnz1.14.18.2
PRIAM enzyme-specific profiles1.14.18.2
KEGG Ligand Database for Enzyme Nomenclature1.14.18.2
IUBMB Enzyme Nomenclature1.14.18.2
IntEnz1.14.18.2
MEDLINEFind literature relating to 1.14.18.2
MetaCyc1.14.18.2
UniProtKB/Swiss-Prot
Q95V11, CMAH_ASTRU;  Q9WV23, CMAH_CRIGR;  Q6GML1, CMAH_DANRE;  
Q8MJC8, CMAH_GORGO;  Q9TUJ2, CMAH_MACMU;  Q61419, CMAH_MOUSE;  
Q8MJD0, CMAH_PANPA;  O97598, CMAH_PANTR;  O19074, CMAH_PIG;  
Q8MJC6, CMAH_PONPY;  Q8AVF5, CMAH_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.18.-
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