ENZYME entry: EC 1.14.18.5

Accepted Name
Sphingolipid C4-monooxygenase.
Alternative Name(s)
Sphinganine C4-monooxygenase.
Sphingolipid C4-hydroxylase.
Reaction catalysed
A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H(2)O
Comment(s)
  • The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes.
  • Some enzymes are bifunctional and also catalyze EC 1.14.19.17.
  • Formerly EC 1.14.13.169.
Cross-references
BRENDA1.14.18.5
EC2PDB1.14.18.5
ExplorEnz1.14.18.5
PRIAM enzyme-specific profiles1.14.18.5
KEGG Ligand Database for Enzyme Nomenclature1.14.18.5
IUBMB Enzyme Nomenclature1.14.18.5
IntEnz1.14.18.5
MEDLINEFind literature relating to 1.14.18.5
MetaCyc1.14.18.5
UniProtKB/Swiss-Prot
Q0II71, DEGS2_BOVIN;  G5EC63, DEGS2_CAEEL;  Q6QHC5, DEGS2_HUMAN;  
Q8R2F2, DEGS2_MOUSE;  Q564G3, DEGS2_RAT;  Q8VYI1, SBH1_ARATH;  
Q9AST3, SBH2_ARATH;  

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