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ENZYME entry: EC 188.8.131.52
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|4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
|A phytoceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H(2)O|
- The enzyme, characterized from yeast and mammals, catalyzes the
hydroxylation of carbon 2 of long- or very-long-chain fatty acids
attached to (4R)-4-hydroxysphinganine during de novo ceramide
- The enzymes from yeast and from mammals contain an N-terminal
cytochrome b5 domain that acts as the direct electron donor to the
desaturase active site.
- The newly introduced 2-hydroxyl group has R-configuration.
- Cf. EC 184.108.40.206.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
entries corresponding to 1.14.18.-
entries corresponding to 1.14.-.-
entries corresponding to 1.-.-.-