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ENZYME entry: EC 1.14.18.7

Accepted Name
Dihydroceramide fatty acyl 2-hydroxylase.
Alternative Name(s)
Plant sphingolipid fatty acid 2-hydroxylase.
Reaction catalysed
A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (2'R)-2'-hydroxydihydroceramide + 2 ferricytochrome b5 + H(2)O
Comment(s)
  • The enzyme, characterized from plants, catalyzes the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis.
  • The enzyme requires an external cytochrome b5 as the electron donor.
  • The newly introduced 2-hydroxyl group has R-configuration.
  • Cf. EC 1.14.18.6.
Cross-references
BRENDA1.14.18.7
EC2PDB1.14.18.7
ExplorEnz1.14.18.7
PRIAM enzyme-specific profiles1.14.18.7
KEGG Ligand Database for Enzyme Nomenclature1.14.18.7
IUBMB Enzyme Nomenclature1.14.18.7
IntEnz1.14.18.7
MEDLINEFind literature relating to 1.14.18.7
MetaCyc1.14.18.7
UniProtKB/Swiss-Prot
O48916, FAH1_ARATH;  Q9SUC5, FAH2_ARATH;  

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