ID   1.14.19.3
DE   acyl-CoA 6-desaturase.
AN   Delta(6)-acyl CoA desaturase.
AN   Delta(6)-desaturase.
AN   Delta(6)-fatty acyl-CoA desaturase.
AN   fatty acid 6-desaturase.
AN   fatty acid Delta(6)-desaturase.
AN   linoleate desaturase.
AN   linoleic acid desaturase.
AN   linoleoyl CoA desaturase.
AN   linoleoyl-CoA desaturase.
AN   linoleoyl-coenzyme A desaturase.
AN   long-chain fatty acid Delta(6)-desaturase.
CA   (1) (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) +
CA   O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] +
CA   2 H2O.
CA   (2) (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+)
CA   + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5]
CA   + 2 H2O.
CC   -!- The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs.
CC   -!- It is a front-end desaturase, introducing the new double bond between
CC       a pre-existing double bond and the carboxyl-end of the fatty acid.
CC   -!- The human enzyme has a broad substrate range; it also acts on
CC       palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)-
CC       tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to
CC       (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as
CC       part of a pathway that produces docosahexaenoate.
CC   -!- The enzyme contains a cytochrome b5 domain that is assumed to act in
CC       vivo as the electron donor to the active site of the desaturase.
CC   -!- Formerly EC 1.14.99.25.
DR   B2KKL4, FAD1_SIGCA ;  A4FV48, FADS2_BOVIN;  Q9DEX7, FADS2_DANRE;
DR   O95864, FADS2_HUMAN;  Q4R749, FADS2_MACFA;  Q9Z0R9, FADS2_MOUSE;
DR   B8R1K0, FADS2_PAPAN;  Q5REA7, FADS2_PONAB;  Q9Z122, FADS2_RAT  ;
DR   A0A0C5PRW9, FADS2_TACFU;  Q23221, FAT3_CAEEL ;
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