ID   1.14.19.4
DE   acyl-lipid (11-3)-desaturase.
AN   acyl-lipid 8-desaturase.
AN   Delta(8)-desaturase.
AN   SLD.
CA   (1) an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-
CA   [cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing
CA   glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O.
CA   (2) an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-
CA   [cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-
CA   containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O.
CC   -!- The enzyme, characterized from the protist Euglena gracilis and the
CC       microalga Rebecca salina, introduces a cis double bond at the
CC       8-position in 20-carbon fatty acids that are incorporated into a
CC       glycerolipid and have an existing Delta(11) desaturation.
CC   -!- The enzyme is a front-end desaturase, introducing the new double bond
CC       between the pre-existing double bond and the carboxyl-end of the
CC       fatty acid.
CC   -!- It contains a cytochrome b5 domain that acts as the direct electron
CC       donor to the active site of the desaturase, and does not require an
CC       external cytochrome.
CC   -!- Involved in alternative pathways for the biosynthesis of the
CC       polyunsaturated fatty acids arachidonate and icosapentaenoate.
CC   -!- Formerly EC 1.14.19.n1.
DR   Q9SWQ9, SLD1_EUGGR ;
//