ID   1.14.19.4
DE   Delta(8)-fatty-acid desaturase.
AN   Delta(8)-desaturase.
AN   Delta(8)-sphingolipid desaturase.
AN   EFD1.
AN   SLD.
CA   Phytosphinganine + reduced acceptor + O(2) = Delta(8)-phytosphingenine +
CA   acceptor + 2 H(2)O.
CC   -!- This enzyme, which has been found mainly in plants, introduces a
CC       double bond at Delta(8) of C(18) and C(20) fatty acids.
CC   -!- The enzyme from the marine microalga Euglena gracilis requires a
CC       double bond to be present at Delta(11) and is most active with 20:3
CC       Delta(11,14,17) and 20:2 Delta(11,14) as substrates, although it can
CC       also desaturate 20:1 Delta(11).
CC   -!- The Delta(8)-desaturation pathway represents an alternate pathway for
CC       the synthesis of the polyunsaturated fatty acids arachidonate (C20:4
CC       Delta(5,14)) and eicosapentaenoate (C20:5 Delta(5,17)) in organisms
CC       lacking a Delta(6)-desaturase.
CC   -!- Formerly EC 1.14.19.n1.
PR   PROSITE; PDOC00170;
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