ID 1.14.19.5 DE acyl-CoA 11-(Z)-desaturase. AN Delta(11) desaturase. AN Delta(11)-fatty-acid desaturase. AN Delta(11)-palmitoyl-CoA desaturase. AN fatty acid Delta(11)-desaturase. AN Z/E11-desaturase. CA an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + CA O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + CA 2 H2O. CC -!- The enzyme introduces a cis double bond at position C-11 of saturated CC fatty acyl-CoAs. CC -!- In moths the enzyme participates in the biosynthesis of their sex CC pheromones. CC -!- The enzyme from the marine microalga Thalassiosira pseudonana is CC specific for palmitoyl-CoA (16:0), that from the leafroller moth CC Choristoneura rosaceana desaturates myristoyl-CoA (14:0), while that CC from the moth Spodoptera littoralis accepts both substrates. CC -!- The enzyme contains three histidine boxes that are conserved in all CC desaturases. CC -!- It is membrane-bound, and contains a cytochrome b5-like domain at the CC N-terminus that serves as the electron donor for the active site of CC the desaturase. CC -!- Formerly EC 1.14.19.n2 and EC 1.14.99.32. DR Q8ISS3, ACO11_CHORO; Q6US81, ACO11_SPOLI; O44390, ACO11_TRINI; DR Q75PL7, DESAT_BOMMO; //