ID   1.14.19.6
DE   acyl-CoA (9+3)-desaturase.
AN   Delta(12)(omega(6))-desaturase.
AN   Delta(12) desaturase.
AN   Delta(12) fatty acid desaturase.
AN   Delta(12)-fatty-acid desaturase.
AN   oleoyl-CoA 12-desaturase.
AN   oleoyl-CoA Delta(12) desaturase.
CA   (1) (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 =
CA   (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.
CA   (2) (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 =
CA   (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.
CC   -!- This microsomal enzyme introduces a cis double bond at position 12 of
CC       fatty-acyl-CoAs that contain a cis double bond at position 9.
CC   -!- When acting on 19:1Delta(10) fatty acyl-CoA the enzyme from the
CC       pathogenic protozoan Trypanosoma brucei introduces the new double
CC       bond at position 13, indicating that the new double bond is
CC       introduced three carbons from the existing cis double bond, toward
CC       the methyl-end of the fatty acid.
CC   -!- Formerly EC 1.14.19.n3.
DR   B7SB91, FAD12_ACHDO;  Q9Y8H5, FAD12_MORAP;  P59668, FAD12_MORIS;
DR   B7SB92, FAD12_TRICA;  Q8GZC3, FAD2_VERFO ;  P46313, FAD6E_ARATH;
DR   G5EGA5, FAT2_CAEEL ;
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