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ENZYME

ENZYME entry: EC 1.14.19.72

Accepted Name
(-)-pluviatolide synthase
Alternative Name(s)
CYP719A23
Reaction catalysed
(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyzes the formation of a methylenedioxy-bridge.
  • It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
  • Formerly EC 1.14.21.11.
Cross-references
BRENDA1.14.19.72
EC2PDB1.14.19.72
ExplorEnz1.14.19.72
PRIAM enzyme-specific profiles1.14.19.72
KEGG Ligand Database for Enzyme Nomenclature1.14.19.72
IUBMB Enzyme Nomenclature1.14.19.72
IntEnz1.14.19.72
MEDLINEFind literature relating to 1.14.19.72
MetaCyc1.14.19.72
Rhea expert-curated reactions1.14.19.72
UniProtKB/Swiss-Prot
L7T720, C719A_PODPEL7T8H2, C719A_SINHE

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