ENZYME entry: EC 1.14.21.2

Accepted Name
(S)-cheilanthifoline synthase.
Alternative Name(s)
(S)-scoulerine oxidase (methylenedioxy-bridge-forming).
Reaction catalysed
(S)-scoulerine + NADPH + O(2) <=> (S)-cheilanthifoline + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline from oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine.
  • Formerly EC 1.1.3.33.
Cross-references
BRENDA1.14.21.2
EC2PDB1.14.21.2
ExplorEnz1.14.21.2
PRIAM enzyme-specific profiles1.14.21.2
KEGG Ligand Database for Enzyme Nomenclature1.14.21.2
IUBMB Enzyme Nomenclature1.14.21.2
IntEnz1.14.21.2
MEDLINEFind literature relating to 1.14.21.2
MetaCyc1.14.21.2
UniProtKB/Swiss-Prot
B5UAQ8, C7195_ESCCA;  B1NF20, C719E_ARGME;  

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