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ENZYME entry: EC 1.14.21.3

Accepted Name
Berbamunine synthase.
Alternative Name(s)
(S)-N-methylcoclaurine oxidase (C-O phenol-coupling).
Reaction catalysed
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + NADPH + O(2) <=> berbamunine + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product.
  • Reaction of 2 molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.
  • Formerly EC 1.1.3.34.
Cross-references
PROSITEPDOC00081
BRENDA1.14.21.3
EC2PDB1.14.21.3
ExplorEnz1.14.21.3
PRIAM enzyme-specific profiles1.14.21.3
KEGG Ligand Database for Enzyme Nomenclature1.14.21.3
IUBMB Enzyme Nomenclature1.14.21.3
IntEnz1.14.21.3
MEDLINEFind literature relating to 1.14.21.3
MetaCyc1.14.21.3
UniProtKB/Swiss-Prot
P47195, C80A1_BERST

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