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ENZYME entry: EC 1.14.21.5

Accepted Name
(S)-canadine synthase.
Alternative Name(s)
(S)-tetrahydroberberine synthase.
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming).
Reaction catalysed
(S)-tetrahydrocolumbamine + NADPH + O(2) <=> (S)-canadine + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
  • Formerly EC 1.1.3.36.
Cross-references
PROSITEPDOC00081
BRENDA1.14.21.5
EC2PDB1.14.21.5
ExplorEnz1.14.21.5
PRIAM enzyme-specific profiles1.14.21.5
KEGG Ligand Database for Enzyme Nomenclature1.14.21.5
IUBMB Enzyme Nomenclature1.14.21.5
IntEnz1.14.21.5
MEDLINEFind literature relating to 1.14.21.5
MetaCyc1.14.21.5
UniProtKB/Swiss-Prot
Q948Y1, C719A_COPJA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.21.-
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