To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.14.21.5

Accepted Name
(S)-canadine synthase.
Alternative Name(s)
(S)-tetrahydroberberine synthase.
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming).
Reaction catalysed
(S)-tetrahydrocolumbamine + NADPH + O(2) <=> (S)-canadine + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
  • Formerly EC 1.1.3.36.
Cross-references
PROSITEPDOC00081
BRENDA1.14.21.5
EC2PDB1.14.21.5
ExplorEnz1.14.21.5
PRIAM enzyme-specific profiles1.14.21.5
KEGG Ligand Database for Enzyme Nomenclature1.14.21.5
IUBMB Enzyme Nomenclature1.14.21.5
IntEnz1.14.21.5
MEDLINEFind literature relating to 1.14.21.5
MetaCyc1.14.21.5
UniProtKB/Swiss-Prot
Q948Y1, C719A_COPJA

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-