ENZYME entry: EC 1.14.99.10

Accepted Name
Steroid 21-monooxygenase.
Alternative Name(s)
CYP21A2.
Cytochrome p450 XXIA1.
Steroid 21-hydroxylase.
Reaction catalysed
A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O(2) <=> a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Requires NADPH and EC 1.6.2.4.
  • Responsible for the conversion of progesterone and 17-alpha- hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol.
  • Involved in the biosynthesis of the hormones aldosterone and cortisol.
  • Formerly EC 1.14.1.8 and EC 1.99.1.11.
Cross-references
PROSITEPDOC00081
BRENDA1.14.99.10
EC2PDB1.14.99.10
ExplorEnz1.14.99.10
PRIAM enzyme-specific profiles1.14.99.10
KEGG Ligand Database for Enzyme Nomenclature1.14.99.10
IUBMB Enzyme Nomenclature1.14.99.10
IntEnz1.14.99.10
MEDLINEFind literature relating to 1.14.99.10
MetaCyc1.14.99.10
UniProtKB/Swiss-Prot
P00191, CP21A_BOVIN;  Q8WNW0, CP21A_CANFA;  Q2LCM1, CP21A_CANLU;  
Q2LA60, CP21A_FELCA;  P08686, CP21A_HUMAN;  Q2LA59, CP21A_LYNLY;  
P03940, CP21A_MOUSE;  P15540, CP21A_PIG;  Q64562, CP21A_RAT;  

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