ENZYME entry: EC 1.14.99.10
| Accepted Name |
|---|
| Steroid 21-monooxygenase.
|
| Alternative Name(s) |
|---|
| CYP21A2. |
| Cytochrome p450 XXIA1. |
| Steroid 21-hydroxylase. |
| Reaction catalysed |
|---|
| A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O(2) <=> a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Requires NADPH and EC 1.6.2.4.
- Responsible for the conversion of progesterone and 17-alpha-
hydroxyprogesterone to their respective 21-hydroxylated derivatives,
11-deoxycorticosterone and 11-deoxycortisol.
- Involved in the biosynthesis of the hormones aldosterone and
cortisol.
- Formerly EC 1.14.1.8 and EC 1.99.1.11.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.99.10 |
| EC2PDB | 1.14.99.10 |
| ExplorEnz | 1.14.99.10 |
| PRIAM enzyme-specific profiles | 1.14.99.10 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.99.10 |
| IUBMB Enzyme Nomenclature | 1.14.99.10 |
| IntEnz | 1.14.99.10 |
| MEDLINE | Find literature relating to 1.14.99.10 |
| MetaCyc | 1.14.99.10 |
| UniProtKB/Swiss-Prot |
|
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