ENZYME entry: EC 1.14.99.29

Accepted Name
Deoxyhypusine monooxygenase.
Alternative Name(s)
Deoxyhypusine dioxygenase.
Deoxyhypusine hydroxylase.
DOHH.
Reaction catalysed
Protein N(6)-(4-aminobutyl)-L-lysine + AH(2) + O(2) <=> protein N(6)-((R)-4-amino-2-hydroxybutyl)-L-lysine + A + H(2)O
Comment(s)
Catalyzes the final step in the formation of the amino acid hypusine in eukaryotic initiation factor 5A (eIF-5A) (formerly eIF-4D).
Cross-references
BRENDA1.14.99.29
EC2PDB1.14.99.29
ExplorEnz1.14.99.29
PRIAM enzyme-specific profiles1.14.99.29
KEGG Ligand Database for Enzyme Nomenclature1.14.99.29
IUBMB Enzyme Nomenclature1.14.99.29
IntEnz1.14.99.29
MEDLINEFind literature relating to 1.14.99.29
MetaCyc1.14.99.29
UniProtKB/Swiss-Prot
Q2QXB3, DOHH1_ORYSJ;  Q2QLW3, DOHH2_ORYSJ;  Q94JW0, DOHH_ARATH;  
Q752Z8, DOHH_ASHGO;  A1CED0, DOHH_ASPCL;  Q4WHG5, DOHH_ASPFU;  
A2QXL3, DOHH_ASPNC;  Q2UMQ8, DOHH_ASPOR;  Q0VC53, DOHH_BOVIN;  
Q17949, DOHH_CAEEL;  Q59Z14, DOHH_CANAL;  Q6FUV3, DOHH_CANGA;  
Q2H0C0, DOHH_CHAGB;  Q5ZIP3, DOHH_CHICK;  Q1E9L2, DOHH_COCIM;  
P0CN11, DOHH_CRYNB;  P0CN10, DOHH_CRYNJ;  Q7ZUX6, DOHH_DANRE;  
Q6BKA6, DOHH_DEBHA;  Q556G4, DOHH_DICDI;  Q9V9U4, DOHH_DROME;  
Q297S2, DOHH_DROPS;  Q5AW32, DOHH_EMENI;  Q8SV71, DOHH_ENCCU;  
Q4HZ35, DOHH_GIBZE;  Q9BU89, DOHH_HUMAN;  Q6CV81, DOHH_KLULA;  
Q96WP5, DOHH_LENED;  Q99LN9, DOHH_MOUSE;  A1DFW7, DOHH_NEOFI;  
Q7S891, DOHH_NEUCR;  Q0UHL8, DOHH_PHANO;  Q5PPJ4, DOHH_RAT;  
Q9P6K9, DOHH_SCHPO;  Q4PHU4, DOHH_USTMA;  Q66KT3, DOHH_XENLA;  
Q6CHJ7, DOHH_YARLI;  P47120, DOHH_YEAST;  

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