ENZYME entry: EC 1.14.99.3

Accepted Name
Heme oxygenase.
Alternative Name(s)
Heme oxidase.
Heme oxygenase (decyclizing).
Reaction catalysed
Heme + 3 AH(2) + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O
Comment(s)
  • Requires NAD(P)H and EC 1.6.2.4.
  • The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
  • The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
  • The central iron is kept in the reduced state by NAD(P)H.
Cross-references
PROSITEPDOC00512
BRENDA1.14.99.3
EC2PDB1.14.99.3
ExplorEnz1.14.99.3
PRIAM enzyme-specific profiles1.14.99.3
KEGG Ligand Database for Enzyme Nomenclature1.14.99.3
IUBMB Enzyme Nomenclature1.14.99.3
IntEnz1.14.99.3
MEDLINEFind literature relating to 1.14.99.3
MetaCyc1.14.99.3
UniProtKB/Swiss-Prot
O48782, HMOX1_ARATH;  Q5E9F2, HMOX1_BOVIN;  P14791, HMOX1_CHICK;  
P09601, HMOX1_HUMAN;  P14901, HMOX1_MOUSE;  Q69XJ4, HMOX1_ORYSJ;  
P32394, HMOX1_PIG;  Q5R7E3, HMOX1_PONAB;  P06762, HMOX1_RAT;  
P30519, HMOX2_HUMAN;  Q2PG53, HMOX2_MACFA;  O70252, HMOX2_MOUSE;  
P43242, HMOX2_RABIT;  P23711, HMOX2_RAT;  Q9C9L4, HMOX3_ARATH;  
O70453, HMOX3_RAT;  Q9LQC0, HMOX4_ARATH;  O73688, HMOX_TAKRU;  
P71119, HMUO_CORDI;  Q8YVS7, HO1_NOSS1;  P72849, HO1_SYNY3;  
P74133, HO2_SYNY3;  O78497, HO_GUITH;  P51271, HO_PORPU;  
Q1XDL5, HO_PORYE;  O19998, HO_RHOVL;  C3PAD1, ISDG_BACAA;  
C3L7Z8, ISDG_BACAC;  A0RJE3, ISDG_BACAH;  Q81L50, ISDG_BACAN;  
B7JR48, ISDG_BACC0;  Q72ZK2, ISDG_BACC1;  B7IJU1, ISDG_BACC2;  
C1ETY1, ISDG_BACC3;  B7HF56, ISDG_BACC4;  B7HRI4, ISDG_BACC7;  
B9J044, ISDG_BACCQ;  Q812Q3, ISDG_BACCR;  Q633Q1, ISDG_BACCZ;  
Q9K7R6, ISDG_BACHD;  Q6HCY5, ISDG_BACHK;  Q5WCF2, ISDG_BACSK;  
A9VJK2, ISDG_BACWK;  Q7AP29, ISDG_LISIN;  C1KZZ5, ISDG_LISMC;  
Q723G7, ISDG_LISMF;  B8DCJ3, ISDG_LISMH;  Q92EH3, ISDG_LISMO;  
A0AFT8, ISDG_LISW6;  A7WXE5, ISDG_STAA1;  Q2FHU5, ISDG_STAA3;  
Q2FZE2, ISDG_STAA8;  Q2YX89, ISDG_STAAB;  Q5HGU8, ISDG_STAAC;  
Q99UW8, ISDG_STAAM;  Q7A649, ISDG_STAAN;  Q6GHV0, ISDG_STAAR;  
Q6GA79, ISDG_STAAS;  A8Z1R5, ISDG_STAAT;  Q8NX62, ISDG_STAAW;  
Q5HM56, ISDG_STAEQ;  Q8CRK4, ISDG_STAES;  Q4L849, ISDG_STAHJ;  
Q49ZB8, ISDG_STAS1;  Q2FK96, ISDI_STAA3;  Q2G1J2, ISDI_STAA8;  
Q5HJK5, ISDI_STAAC;  Q99X56, ISDI_STAAM;  Q7A827, ISDI_STAAN;  
Q6GKE0, ISDI_STAAR;  Q6GCW1, ISDI_STAAS;  Q7A1Y8, ISDI_STAAW;  

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