ID   1.14.99.3
DE   Heme oxygenase.
AN   Heme oxidase.
AN   Heme oxygenase (decyclizing).
CA   Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.
CC   -!- Requires NAD(P)H and EC 1.6.2.4.
CC   -!- The terminal oxygen atoms that are incorporated into the carbonyl
CC       groups of pyrrole rings A and B of biliverdin are derived from two
CC       separate oxygen molecules.
CC   -!- The third oxygen molecule provides the oxygen atom that converts the
CC       alpha-carbon to CO.
CC   -!- The central iron is kept in the reduced state by NAD(P)H.
PR   PROSITE; PDOC00512;
DR   O48782, HMOX1_ARATH;  Q5E9F2, HMOX1_BOVIN;  P14791, HMOX1_CHICK;
DR   P09601, HMOX1_HUMAN;  P14901, HMOX1_MOUSE;  Q69XJ4, HMOX1_ORYSJ;
DR   P32394, HMOX1_PIG  ;  Q5R7E3, HMOX1_PONAB;  P06762, HMOX1_RAT  ;
DR   P30519, HMOX2_HUMAN;  Q2PG53, HMOX2_MACFA;  O70252, HMOX2_MOUSE;
DR   P43242, HMOX2_RABIT;  P23711, HMOX2_RAT  ;  Q9C9L4, HMOX3_ARATH;
DR   O70453, HMOX3_RAT  ;  Q9LQC0, HMOX4_ARATH;  O73688, HMOX_TAKRU ;
DR   P71119, HMUO_CORDI ;  Q8YVS7, HO1_NOSS1  ;  P72849, HO1_SYNY3  ;
DR   P74133, HO2_SYNY3  ;  O78497, HO_GUITH   ;  P51271, HO_PORPU   ;
DR   Q1XDL5, HO_PORYE   ;  O19998, HO_RHOVL   ;  C3PAD1, ISDG_BACAA ;
DR   C3L7Z8, ISDG_BACAC ;  A0RJE3, ISDG_BACAH ;  Q81L50, ISDG_BACAN ;
DR   B7JR48, ISDG_BACC0 ;  Q72ZK2, ISDG_BACC1 ;  B7IJU1, ISDG_BACC2 ;
DR   C1ETY1, ISDG_BACC3 ;  B7HF56, ISDG_BACC4 ;  B7HRI4, ISDG_BACC7 ;
DR   B9J044, ISDG_BACCQ ;  Q812Q3, ISDG_BACCR ;  Q633Q1, ISDG_BACCZ ;
DR   Q9K7R6, ISDG_BACHD ;  Q6HCY5, ISDG_BACHK ;  Q5WCF2, ISDG_BACSK ;
DR   A9VJK2, ISDG_BACWK ;  Q7AP29, ISDG_LISIN ;  C1KZZ5, ISDG_LISMC ;
DR   Q723G7, ISDG_LISMF ;  B8DCJ3, ISDG_LISMH ;  Q92EH3, ISDG_LISMO ;
DR   A0AFT8, ISDG_LISW6 ;  A7WXE5, ISDG_STAA1 ;  Q2FHU5, ISDG_STAA3 ;
DR   Q2FZE2, ISDG_STAA8 ;  Q2YX89, ISDG_STAAB ;  Q5HGU8, ISDG_STAAC ;
DR   Q99UW8, ISDG_STAAM ;  Q7A649, ISDG_STAAN ;  Q6GHV0, ISDG_STAAR ;
DR   Q6GA79, ISDG_STAAS ;  A8Z1R5, ISDG_STAAT ;  Q8NX62, ISDG_STAAW ;
DR   Q5HM56, ISDG_STAEQ ;  Q8CRK4, ISDG_STAES ;  Q4L849, ISDG_STAHJ ;
DR   Q49ZB8, ISDG_STAS1 ;  Q2FK96, ISDI_STAA3 ;  Q2G1J2, ISDI_STAA8 ;
DR   Q5HJK5, ISDI_STAAC ;  Q99X56, ISDI_STAAM ;  Q7A827, ISDI_STAAN ;
DR   Q6GKE0, ISDI_STAAR ;  Q6GCW1, ISDI_STAAS ;  Q7A1Y8, ISDI_STAAW ;
//