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ENZYME entry: EC 220.127.116.11
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|Cholesterol + AH(2) + O(2) <=> 25-hydroxycholesterol + A + H(2)O|
- Unlike most other sterol hydroxylases, this enzyme is not a
- Instead, it uses diiron cofactors to catalyze the hydroxylation of
- The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to
the enzyme through interactions with clustered histidine or glutamate
- In cell cultures, this enzyme down-regulates cholesterol synthesis
and the processing of sterol regulatory element binding proteins
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
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entries corresponding to 1.14.99.-
entries corresponding to 1.14.-.-
entries corresponding to 1.-.-.-