ENZYME entry: EC 1.14.99.48

Accepted Name
Heme oxygenase (staphylobilin-producing).
Alternative Name(s)
Heme oxidase.
Heme oxygenase.
Heme oxygenase (decyclizing).
Reaction catalysed
  • Protoheme + 4 AH(2) + 4 O(2) <=> 5-oxo-delta-bilirubin + Fe(2+) + CO + 4 A + 4 H(2)O
  • Protoheme + 4 AH(2) + 4 O(2) <=> 15-oxo-beta-bilirubin + Fe(2+) + CO + 4 A + 4 H(2)O
Comment(s)
  • This enzyme, which is found in pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin.
  • The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % 5-oxo-delta- bilirubin, respectively.
Cross-references
BRENDA1.14.99.48
EC2PDB1.14.99.48
ExplorEnz1.14.99.48
PRIAM enzyme-specific profiles1.14.99.48
KEGG Ligand Database for Enzyme Nomenclature1.14.99.48
IUBMB Enzyme Nomenclature1.14.99.48
IntEnz1.14.99.48
MEDLINEFind literature relating to 1.14.99.48
MetaCyc1.14.99.48
UniProtKB/Swiss-Prot
Q2FHU5, HDOX1_STAA3;  Q2FZE2, HDOX1_STAA8;  Q5HGU8, HDOX1_STAAC;  
A6QG37, HDOX1_STAAE;  Q99UW8, HDOX1_STAAM;  Q7A649, HDOX1_STAAN;  
Q6GHV0, HDOX1_STAAR;  Q6GA79, HDOX1_STAAS;  Q8NX62, HDOX1_STAAW;  
Q2FK96, HDOX2_STAA3;  Q2G1J2, HDOX2_STAA8;  Q5HJK5, HDOX2_STAAC;  
A6QDF1, HDOX2_STAAE;  Q99X56, HDOX2_STAAM;  Q7A827, HDOX2_STAAN;  
Q6GKE0, HDOX2_STAAR;  Q6GCW1, HDOX2_STAAS;  Q7A1Y8, HDOX2_STAAW;  
A7WXE5, HDOX_STAA1;  Q2YX89, HDOX_STAAB;  A8Z1R5, HDOX_STAAT;  
Q5HM56, HDOX_STAEQ;  Q8CRK4, HDOX_STAES;  Q4L849, HDOX_STAHJ;  
Q49ZB8, HDOX_STAS1;  

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