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ENZYME

ENZYME entry: EC 1.14.99.68

Accepted Name
4-aminobenzoate N-oxygenase
Reaction catalysed
4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyzes an early step in the biosynthesis of the antibiotic aureothin.
  • It contains a carboxylate-bridged binuclear non-heme iron cluster.
  • The native electron donor has not been identified, but is likely an iron-sulfur protein.
  • The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyzes three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates. cf. EC 1.14.99.67.
Cross-references
BRENDA1.14.99.68
EC2PDB1.14.99.68
ExplorEnz1.14.99.68
PRIAM enzyme-specific profiles1.14.99.68
KEGG Ligand Database for Enzyme Nomenclature1.14.99.68
IUBMB Enzyme Nomenclature1.14.99.68
IntEnz1.14.99.68
MEDLINEFind literature relating to 1.14.99.68
MetaCyc1.14.99.68
Rhea expert-curated reactions1.14.99.68
UniProtKB/Swiss-Prot
Q70KH9, AURF_STRTU

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