Expasy logo

ENZYME

ENZYME entry: EC 1.14.99.69

Accepted Name
tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase
Alternative Name(s)
tRNA 2-(methylsulfanyl)-N(6)-dimethylallyladenosine(37) hydroxylase
tRNA 2-methylthio-N(6)-isopentenyl adenosine(37) hydroxylase
Reaction catalysed
2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA
Comment(s)
  • The enzyme, found only within a small subset of facultative anaerobic bacteria, belongs to the nonheme diiron family.
  • The enzyme from Salmonella typhimurium was shown to catalyze a stereoselective (E) hydroxylation at the terminal C(4)-position of the prenyl group.
Cross-references
BRENDA1.14.99.69
EC2PDB1.14.99.69
ExplorEnz1.14.99.69
PRIAM enzyme-specific profiles1.14.99.69
KEGG Ligand Database for Enzyme Nomenclature1.14.99.69
IUBMB Enzyme Nomenclature1.14.99.69
IntEnz1.14.99.69
MEDLINEFind literature relating to 1.14.99.69
MetaCyc1.14.99.69
Rhea expert-curated reactions1.14.99.69
UniProtKB/Swiss-Prot
Q88KV1, MIAE_PSEPKQ08015, MIAE_SALTY

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-