ID   1.16.1.6
DE   cyanocobalamin reductase.
AN   cyanocobalamin reductase (cyanide-eliminating).
AN   cyanocobalamin reductase (NADPH, cyanide-eliminating).
AN   cyanocobalamin reductase (NADPH; CN-eliminating).
AN   NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating).
CA   2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)
CA   = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) +
CA   NADPH.
CC   -!- The mammalian enzyme, which is cytosolic, can bind internalized
CC       cyanocobalamin and process it to cob(II)alamin by removing the upper
CC       axial ligand.
CC   -!- The product remains bound to the protein, which, together with its
CC       interacting partner MMADHC, transfers it directly to downstream
CC       enzymes involved in adenosylcobalamin and methylcobalamin
CC       biosynthesis.
CC   -!- In addition to its decyanase function, the mammalian enzyme also
CC       catalyzes an entirely different chemical reaction with
CC       alkylcobalamins, using the thiolate of glutathione for nucleophilic
CC       displacement, generating cob(I)alamin and the corresponding
CC       glutathione thioether (cf. EC 2.5.1.151).
CC   -!- Formerly EC 1.6.99.12.
DR   Q5E9C8, MMAC_BOVIN ;  Q5ZL21, MMAC_CHICK ;  Q5RFU5, MMAC_DANRE ;
DR   Q9Y4U1, MMAC_HUMAN ;  Q9CZD0, MMAC_MOUSE ;
//