ID 1.16.1.8 DE [methionine synthase] reductase. AN [methionine synthase]-cobalamin methyltransferase (cob(II)alamin AN reducing). AN methionine synthase cob(II)alamin reductase (methylating). AN methionine synthase reductase. CA H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + CA 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + CA NADPH + 2 S-adenosyl-L-methionine. CC -!- The substrate of the enzyme is the inactivated cobalt(II) form of CC EC 2.1.1.13. CC -!- Electrons are transferred from NADPH to FAD to FMN. CC -!- Formerly EC 2.1.1.135. DR Q4JIJ2, MTRR_BOVIN ; Q17574, MTRR_CAEEL ; Q9UBK8, MTRR_HUMAN ; DR Q8C1A3, MTRR_MOUSE ; Q498R1, MTRR_RAT ; //