ENZYME entry: EC 1.17.1.1

PURL: https://purl.expasy.org/enzyme/EC/1.17.1.1

Accepted Name
CDP-4-dehydro-6-deoxyglucose reductase
Alternative Name(s)
CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system
CDP-4-keto-6-deoxyglucose reductase
CDP-4-keto-deoxy-glucose reductase
cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase
cytidine diphospho-4-keto-6-deoxy-D-glucose reductase
NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase
Reaction catalysed
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NAD(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H(+) CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADP(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H(+)
Comment(s)
The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyzes the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.
Cross-references
BRENDA	1.17.1.1
EC2PDB	1.17.1.1
ExplorEnz	1.17.1.1
KEGG Ligand Database for Enzyme Nomenclature	1.17.1.1
IUBMB Enzyme Nomenclature	1.17.1.1
MEDLINE	Find literature relating to 1.17.1.1
MetaCyc	1.17.1.1
Rhea expert-curated reactions	1.17.1.1

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