ENZYME entry: EC 1.17.1.2

Accepted Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase.
Alternative Name(s)
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase.
HMBPP reductase.
Reaction catalysed
  • Isopentenyl diphosphate + NAD(P)(+) + H(2)O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
  • Dimethylallyl diphosphate + NAD(P)(+) + H(2)O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Comprises a system in which ferredoxin is first reduced and subsequently reoxidized by an NAD(P)(+)-dependent reductase.
  • This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis.
  • Acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and dimethyallyl diphosphate.
Cross-references
BRENDA1.17.1.2
EC2PDB1.17.1.2
ExplorEnz1.17.1.2
PRIAM enzyme-specific profiles1.17.1.2
KEGG Ligand Database for Enzyme Nomenclature1.17.1.2
IUBMB Enzyme Nomenclature1.17.1.2
IntEnz1.17.1.2
MEDLINEFind literature relating to 1.17.1.2
MetaCyc1.17.1.2
UniProtKB/Swiss-Prot
Q89UU5, ISPH1_BRADU;  Q629Z7, ISPH1_BURMA;  Q63WH0, ISPH1_BURPS;  
P0A5I1, ISPH1_MYCBO;  P9WKG0, ISPH1_MYCTO;  P9WKG1, ISPH1_MYCTU;  
Q6N3G0, ISPH1_RHOPA;  Q89QW7, ISPH2_BRADU;  Q62HM8, ISPH2_BURMA;  
I1WW99, ISPH2_BURP2;  P0DMK8, ISPH2_BURPS;  P0A5I3, ISPH2_MYCBO;  
P9WKF8, ISPH2_MYCTO;  P9WKF9, ISPH2_MYCTU;  Q6N1Y1, ISPH2_RHOPA;  
B0C4N8, ISPH_ACAM1;  Q9RBJ0, ISPH_ACIAD;  B7GVR1, ISPH_ACIB3;  
B7IAU0, ISPH_ACIB5;  B2HZW3, ISPH_ACIBC;  B0VQ53, ISPH_ACIBS;  
A3M9H2, ISPH_ACIBT;  B0V8K4, ISPH_ACIBY;  A0LW20, ISPH_ACIC1;  
B7JBD6, ISPH_ACIF2;  B5ERJ7, ISPH_ACIF5;  A3N2G8, ISPH_ACTP2;  
B3GYK1, ISPH_ACTP7;  B0BRB3, ISPH_ACTPJ;  A6VQH8, ISPH_ACTSZ;  
A0KG42, ISPH_AERHH;  A4SIX8, ISPH_AERS4;  B9JAQ2, ISPH_AGRRK;  
P58673, ISPH_AGRT5;  Q0VSD8, ISPH_ALCBS;  B6ENC7, ISPH_ALISL;  
A6TRF9, ISPH_ALKMQ;  A8MFE2, ISPH_ALKOO;  A7HCQ8, ISPH_ANADF;  
B9KIX9, ISPH_ANAMF;  Q5PAE7, ISPH_ANAMM;  B4UEK4, ISPH_ANASK;  
Q3M8X6, ISPH_ANAVT;  B7GH78, ISPH_ANOFW;  O67625, ISPH_AQUAE;  
Q94B35, ISPH_ARATH;  Q5P224, ISPH_AROAE;  B6YQB8, ISPH_AZOPC;  
A1K4R4, ISPH_AZOSB;  C1DPH8, ISPH_AZOVD;  A7Z6T1, ISPH_BACA2;  
C3P8J4, ISPH_BACAA;  C3LKW7, ISPH_BACAC;  A0RIR1, ISPH_BACAH;  
Q81LU9, ISPH_BACAN;  B7JN13, ISPH_BACC0;  Q730P8, ISPH_BACC1;  
B7IYD9, ISPH_BACC2;  C1ESI2, ISPH_BACC3;  B7HCR2, ISPH_BACC4;  
B7HPI8, ISPH_BACC7;  A7GSY4, ISPH_BACCN;  B9IY56, ISPH_BACCQ;  
Q634Q0, ISPH_BACCZ;  Q5L9K3, ISPH_BACFN;  Q64PU1, ISPH_BACFR;  
Q9KD37, ISPH_BACHD;  Q6HDN0, ISPH_BACHK;  Q65H97, ISPH_BACLD;  
A8FFA1, ISPH_BACP2;  Q5WHC6, ISPH_BACSK;  P54473, ISPH_BACSU;  
Q8A625, ISPH_BACTN;  A6L1P5, ISPH_BACV8;  A9VHR7, ISPH_BACWK;  
A1URX2, ISPH_BARBK;  Q6G4C5, ISPH_BARHE;  Q6G0C9, ISPH_BARQU;  
A9IQQ9, ISPH_BART1;  Q1LSS7, ISPH_BAUCH;  B2IED0, ISPH_BEII9;  
Q8G4L8, ISPH_BIFLO;  Q493S1, ISPH_BLOPB;  Q7WHF2, ISPH_BORBR;  
Q7W9B4, ISPH_BORPA;  Q7VYS2, ISPH_BORPE;  C0ZL73, ISPH_BREBN;  
B2S9W9, ISPH_BRUA1;  Q57EP6, ISPH_BRUAB;  Q8YFR1, ISPH_BRUME;  
Q8G257, ISPH_BRUSU;  B8D8U8, ISPH_BUCA5;  P57247, ISPH_BUCAI;  
Q8K9Z4, ISPH_BUCAP;  B8D752, ISPH_BUCAT;  A7ZCD0, ISPH_CAMC1;  
A7GXB5, ISPH_CAMC5;  A0RQC4, ISPH_CAMFF;  A7I0N0, ISPH_CAMHC;  
A8FLU3, ISPH_CAMJ8;  A7H3F3, ISPH_CAMJD;  P0C632, ISPH_CAMJE;  
A1VZM8, ISPH_CAMJJ;  Q5HUR4, ISPH_CAMJR;  B9KD74, ISPH_CAMLR;  
Q9A345, ISPH_CAUCR;  Q11KC7, ISPH_CHESB;  Q5L5D3, ISPH_CHLAB;  
Q3AT23, ISPH_CHLCH;  Q822D9, ISPH_CHLCV;  Q255J4, ISPH_CHLFF;  
B3EFF5, ISPH_CHLL2;  Q9PL59, ISPH_CHLMU;  B3QQE0, ISPH_CHLP8;  
B3EM42, ISPH_CHLPB;  A1BDJ5, ISPH_CHLPD;  Q9Z6P2, ISPH_CHLPN;  
B0B991, ISPH_CHLT2;  B3QSU2, ISPH_CHLT3;  Q3KKH8, ISPH_CHLTA;  
B0BAX0, ISPH_CHLTB;  Q8KFN9, ISPH_CHLTE;  O84867, ISPH_CHLTR;  
Q1R0B2, ISPH_CHRSD;  Q7NS59, ISPH_CHRVO;  A8ALT3, ISPH_CITK8;  
Q97I09, ISPH_CLOAB;  Q0TRF3, ISPH_CLOP1;  P58675, ISPH_CLOPE;  
Q0STT3, ISPH_CLOPS;  Q895G2, ISPH_CLOTE;  Q486R1, ISPH_COLP3;  
Q6NI36, ISPH_CORDI;  Q8FQP0, ISPH_COREF;  A4QCY9, ISPH_CORGB;  
Q8NRM2, ISPH_CORGL;  A7MIM0, ISPH_CROS8;  B1WTZ2, ISPH_CYAA5;  
B8HWD3, ISPH_CYAP4;  B7KEG3, ISPH_CYAP7;  B7K4V8, ISPH_CYAP8;  
Q11YY5, ISPH_CYTH3;  Q47BK8, ISPH_DECAR;  Q3Z6U4, ISPH_DEHM1;  
A5FPY7, ISPH_DEHMB;  Q3ZYL6, ISPH_DEHMC;  Q9RSG0, ISPH_DEIRA;  
Q316F5, ISPH_DESAG;  B8J3G9, ISPH_DESDA;  C4XUD2, ISPH_DESMR;  
Q6AL80, ISPH_DESPS;  Q72G08, ISPH_DESVH;  B8DMK7, ISPH_DESVM;  
A1VHK1, ISPH_DESVV;  B5YEC2, ISPH_DICT6;  B8E2T7, ISPH_DICTD;  
A8LLC7, ISPH_DINSH;  A7ZHB8, ISPH_ECO24;  B7UI74, ISPH_ECO27;  
B7MAE9, ISPH_ECO45;  B7L4F1, ISPH_ECO55;  P62625, ISPH_ECO57;  
B5YYC1, ISPH_ECO5E;  B7NHD3, ISPH_ECO7I;  B7MNN4, ISPH_ECO81;  
B7M0C5, ISPH_ECO8A;  C4ZPV5, ISPH_ECOBW;  B1XBF4, ISPH_ECODH;  
A7ZVX7, ISPH_ECOHS;  A1A777, ISPH_ECOK1;  Q0TLW2, ISPH_ECOL5;  
P62624, ISPH_ECOL6;  B1IRE6, ISPH_ECOLC;  P62623, ISPH_ECOLI;  
B7N7Q3, ISPH_ECOLU;  B6HYX7, ISPH_ECOSE;  B1LFV9, ISPH_ECOSM;  
Q1RGH3, ISPH_ECOUT;  C5B7M7, ISPH_EDWI9;  Q5FFL5, ISPH_EHRRG;  
Q5HB13, ISPH_EHRRW;  A4W6E4, ISPH_ENT38;  B2VH04, ISPH_ERWT9;  
B7LVN5, ISPH_ESCF3;  B1YL84, ISPH_EXIS2;  C4L3Z5, ISPH_EXISA;  
B0U064, ISPH_FRAP2;  Q14I06, ISPH_FRAT1;  A7NA22, ISPH_FRATF;  
Q2A587, ISPH_FRATH;  B2SES8, ISPH_FRATM;  A0Q4T9, ISPH_FRATN;  
Q0BNK1, ISPH_FRATO;  Q5NGK4, ISPH_FRATT;  A4IYW2, ISPH_FRATW;  
Q8RI52, ISPH_FUSNN;  B5E9S9, ISPH_GEOBB;  B9LZG4, ISPH_GEODF;  
Q5KX24, ISPH_GEOKA;  B3E441, ISPH_GEOLS;  Q39XB6, ISPH_GEOMG;  
Q749Y8, ISPH_GEOSL;  C6E2B3, ISPH_GEOSM;  C5D4R3, ISPH_GEOSW;  
A4IR05, ISPH_GEOTN;  A5GE10, ISPH_GEOUR;  Q7NG74, ISPH_GLOVI;  
Q5FUH7, ISPH_GLUOX;  Q7VPK4, ISPH_HAEDU;  Q4QLQ5, ISPH_HAEI8;  
A5UD69, ISPH_HAEIE;  A5UID9, ISPH_HAEIG;  P44976, ISPH_HAEIN;  
B8F6E6, ISPH_HAEPS;  Q2S9U2, ISPH_HAHCH;  C4K4R2, ISPH_HAMD5;  
Q7VJV5, ISPH_HELHP;  B6JMP4, ISPH_HELP2;  Q1CSL3, ISPH_HELPH;  
P65186, ISPH_HELPJ;  B2UUG0, ISPH_HELPS;  P65185, ISPH_HELPY;  
B0UV08, ISPH_HISS2;  Q0BYQ0, ISPH_HYPNA;  Q5QZR7, ISPH_IDILO;  
B5Y232, ISPH_KLEP3;  A6T4G3, ISPH_KLEP7;  C5CIU9, ISPH_KOSOT;  
Q6ADV0, ISPH_LEIXX;  Q72S57, ISPH_LEPIC;  Q8F3I3, ISPH_LEPIN;  
C1KV98, ISPH_LISMC;  Q71ZL9, ISPH_LISMF;  P58676, ISPH_LISMO;  
B1HTG5, ISPH_LYSSC;  B9E6U8, ISPH_MACCJ;  A0LD71, ISPH_MAGSM;  
Q65RQ4, ISPH_MANSM;  A1TYZ2, ISPH_MARAV;  Q607E5, ISPH_METCA;  
A2SJA8, ISPH_METPP;  B8EQB9, ISPH_METSB;  B0JVA7, ISPH_MICAN;  
A4T986, ISPH_MYCGI;  Q9X781, ISPH_MYCLE;  Q73WH6, ISPH_MYCPA;  
Q8EWR9, ISPH_MYCPE;  A3Q4N0, ISPH_MYCSJ;  A1UKL5, ISPH_MYCSK;  
Q1B4H4, ISPH_MYCSS;  A0PKQ3, ISPH_MYCUA;  A1TE06, ISPH_MYCVP;  
B9L9K5, ISPH_NAUPA;  Q5FAF2, ISPH_NEIG1;  B4RPZ2, ISPH_NEIG2;  
A9M1J9, ISPH_NEIM0;  P65191, ISPH_NEIMA;  P65192, ISPH_NEIMB;  
A1KS64, ISPH_NEIMF;  Q2GDX3, ISPH_NEOSM;  Q82WM1, ISPH_NITEU;  
A6Q2R7, ISPH_NITSB;  Q5YQ94, ISPH_NOCFA;  B2IZV5, ISPH_NOSP7;  
P58674, ISPH_NOSS1;  A6WWG6, ISPH_OCHA4;  B1ZXD4, ISPH_OPITP;  
Q6AVG6, ISPH_ORYSJ;  A6LIB3, ISPH_PARD8;  A1B842, ISPH_PARDP;  
Q6MC97, ISPH_PARUW;  P57960, ISPH_PASMU;  Q6D0C6, ISPH_PECAS;  
C6DF01, ISPH_PECCP;  Q3A3D3, ISPH_PELCD;  Q3B241, ISPH_PELLD;  
B4SCU0, ISPH_PELPB;  A1ANP9, ISPH_PELPD;  Q187C6, ISPH_PEPD6;  
A9BGS3, ISPH_PETMO;  B4R8T7, ISPH_PHEZH;  Q7N8W9, ISPH_PHOLL;  
Q6LUK8, ISPH_PHOPR;  Q12EY5, ISPH_POLSJ;  Q7MWK6, ISPH_PORGI;  
B4S4X8, ISPH_PROA2;  Q6AA89, ISPH_PROAC;  A3PAY5, ISPH_PROM0;  
A2C096, ISPH_PROM1;  A2CCK3, ISPH_PROM3;  A9BDN6, ISPH_PROM4;  
A2BUP5, ISPH_PROM5;  Q31CR8, ISPH_PROM9;  Q7VDS2, ISPH_PROMA;  
B4F2T8, ISPH_PROMH;  Q7V4T7, ISPH_PROMM;  Q7V329, ISPH_PROMP;  
A2BP63, ISPH_PROMS;  Q46HB0, ISPH_PROMT;  A4SGC0, ISPH_PROVI;  
Q48NK3, ISPH_PSE14;  Q15R07, ISPH_PSEA6;  B7V0A0, ISPH_PSEA8;  
Q02GC0, ISPH_PSEAB;  Q9HVM7, ISPH_PSEAE;  Q1I4S8, ISPH_PSEE4;  
Q4K5U7, ISPH_PSEF5;  P21864, ISPH_PSEFL;  C3KDX7, ISPH_PSEFS;  
Q3IE99, ISPH_PSEHT;  A4XQV8, ISPH_PSEMY;  A5VY55, ISPH_PSEP1;  
Q3K6L8, ISPH_PSEPF;  B0KM87, ISPH_PSEPG;  Q88Q89, ISPH_PSEPK;  
B1JF80, ISPH_PSEPW;  Q889E1, ISPH_PSESM;  Q4ZYJ1, ISPH_PSEU2;  
Q4FQY8, ISPH_PSYA2;  Q1Q974, ISPH_PSYCK;  A1SZP0, ISPH_PSYIN;  
A5WCZ2, ISPH_PSYWF;  P58677, ISPH_RALSO;  B3PSB9, ISPH_RHIE6;  
Q1MKH8, ISPH_RHIL3;  Q985W3, ISPH_RHILO;  B5ZSV9, ISPH_RHILW;  
Q92RG2, ISPH_RHIME;  Q7ULU1, ISPH_RHOBA;  C1A2V7, ISPH_RHOE4;  
C1AYI4, ISPH_RHOOB;  A3PGE9, ISPH_RHOS1;  Q3J5X0, ISPH_RHOS4;  
A4WVQ4, ISPH_RHOS5;  Q0S489, ISPH_RHOSR;  Q16AJ6, ISPH_ROSDO;  
Q5LNJ7, ISPH_RUEPO;  Q1GDG5, ISPH_RUEST;  A1AXS1, ISPH_RUTMC;  
Q21HK6, ISPH_SACD2;  B5F728, ISPH_SALA4;  A9MR43, ISPH_SALAR;  
Q57TL2, ISPH_SALCH;  B5FHE3, ISPH_SALDC;  B5R1N9, ISPH_SALEP;  
B5RG84, ISPH_SALG2;  B4TIE9, ISPH_SALHS;  B4T6H5, ISPH_SALNS;  
Q5PKI4, ISPH_SALPA;  A9MYG8, ISPH_SALPB;  C0Q4I9, ISPH_SALPC;  
B5BLL3, ISPH_SALPK;  B4TWP0, ISPH_SALSV;  P58678, ISPH_SALTI;  
P58679, ISPH_SALTY;  A8G9L7, ISPH_SERP5;  B0TJB2, ISPH_SHEHH;  
Q8EBI7, ISPH_SHEON;  A8H1H6, ISPH_SHEPA;  B2U248, ISPH_SHIB3;  
Q326J4, ISPH_SHIBS;  Q32K68, ISPH_SHIDS;  Q0T8G5, ISPH_SHIF8;  
Q7UDT8, ISPH_SHIFL;  Q3Z5Y1, ISPH_SHISS;  Q2NVY3, ISPH_SODGM;  
Q82IE8, ISPH_STRAW;  Q9FBM1, ISPH_STRCO;  B1W2D7, ISPH_STRGG;  
B4SP20, ISPH_STRM5;  B2FU83, ISPH_STRMK;  Q30S81, ISPH_SULDN;  
A6Q7P9, ISPH_SULNB;  Q67QZ8, ISPH_SYMTH;  Q31S64, ISPH_SYNE7;  
B1XPG7, ISPH_SYNP2;  Q5N249, ISPH_SYNP6;  A5GIF7, ISPH_SYNPW;  
Q7U9K4, ISPH_SYNPX;  A5GWG3, ISPH_SYNR3;  Q0IDE5, ISPH_SYNS3;  
Q3B080, ISPH_SYNS9;  Q3AN10, ISPH_SYNSC;  Q55643, ISPH_SYNY3;  
Q8DK29, ISPH_THEEB;  A8F7S0, ISPH_THELT;  Q9X1F7, ISPH_THEMA;  
B9K8E2, ISPH_THENN;  A5IME1, ISPH_THEP1;  B0K9L0, ISPH_THEP3;  
B0K197, ISPH_THEPX;  B1LBI2, ISPH_THESQ;  Q72G65, ISPH_THET2;  
Q5SMC8, ISPH_THET8;  Q8RA76, ISPH_THETN;  B8GQR4, ISPH_THISH;  
C4LD10, ISPH_TOLAT;  Q73NQ6, ISPH_TREDE;  O83558, ISPH_TREPA;  
B2S3D9, ISPH_TREPS;  Q10WA8, ISPH_TRIEI;  Q83NB2, ISPH_TROW8;  
Q83MR9, ISPH_TROWT;  A5CVK1, ISPH_VESOH;  Q9KU44, ISPH_VIBCH;  
Q5E7N1, ISPH_VIBF1;  B5FA63, ISPH_VIBFM;  Q87S87, ISPH_VIBPA;  
Q8DET0, ISPH_VIBVU;  Q7MNM5, ISPH_VIBVY;  Q8D2R2, ISPH_WIGBR;  
Q73FQ1, ISPH_WOLPM;  B3CM01, ISPH_WOLPP;  Q7M8Y6, ISPH_WOLSU;  
Q5GTN6, ISPH_WOLTR;  C0R4T5, ISPH_WOLWR;  Q8PN17, ISPH_XANAC;  
Q3BW40, ISPH_XANC5;  Q4US42, ISPH_XANC8;  B0RY26, ISPH_XANCB;  
Q8PBG4, ISPH_XANCP;  Q2P5A8, ISPH_XANOM;  B2STC6, ISPH_XANOP;  
Q5H2D9, ISPH_XANOR;  B2I6V0, ISPH_XYLF2;  P65193, ISPH_XYLFA;  
B0U3Q7, ISPH_XYLFM;  P65194, ISPH_XYLFT;  A1JJE4, ISPH_YERE8;  
A7FMD4, ISPH_YERP3;  Q1C0J0, ISPH_YERPA;  B2K3M9, ISPH_YERPB;  
P58680, ISPH_YERPE;  A9R005, ISPH_YERPG;  Q1CMU8, ISPH_YERPN;  
A4TQF0, ISPH_YERPP;  Q66ES1, ISPH_YERPS;  B1JKZ5, ISPH_YERPY;  
Q5NP61, ISPH_ZYMMO;  

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