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ENZYME entry: EC

Accepted Name
Nicotinate dehydrogenase.
Alternative Name(s)
Nicotinate hydroxylase.
Nicotinic acid hydroxylase.
Reaction catalysed
Nicotinate + H(2)O + NADP(+) <=> 6-hydroxynicotinate + NADPH
Fe cation; Flavoprotein.
  • The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate.
  • The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC, EC, EC, EC, EC, EC and EC
  • Formerly EC
PRIAM enzyme-specific profiles1.17.1.5
KEGG Ligand Database for Enzyme Nomenclature1.17.1.5
IUBMB Enzyme Nomenclature1.17.1.5
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