ID   1.17.4.1
DE   Ribonucleoside-diphosphate reductase.
AN   Ribonucleotide reductase.
CA   2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O =
CA   ribonucleoside diphosphate + thioredoxin.
CF   Iron.
CC   -!- Responsible for the de novo conversion of ribonucleoside diphosphates
CC       into deoxyribonucleoside diphosphates, which are essential for DNA
CC       synthesis and repair.
CC   -!- While the enzyme is activated by ATP, it is inhibited by dATP.
PR   PROSITE; PDOC00084;
PR   PROSITE; PDOC00317;
DR   O64174, BNRDF_BPSPB;  O31875, NRDEB_BACSU;  O64173, NRDEB_BPSPB;
DR   Q8UEM4, NRDJ_AGRT5 ;  Q6MNP6, NRDJ_BDEBA ;  Q89MB9, NRDJ_BRAJA ;
DR   Q72S00, NRDJ_LEPIC ;  Q8F3P1, NRDJ_LEPIN ;  Q7UI46, NRDJ_RHOBA ;
DR   Q82KE2, NRDJ_STRAW ;  O54196, NRDJ_STRCL ;  O69981, NRDJ_STRCO ;
DR   Q9XD73, NRDJ_STRCT ;  O53767, NRDZ_MYCTU ;  P0CG99, RIR1A_MYCS2;
DR   P0CH00, RIR1B_MYCS2;  O36411, RIR1_ALHV1 ;  O66503, RIR1_AQUAE ;
DR   Q9SJ20, RIR1_ARATH ;  P42491, RIR1_ASFB7 ;  P0C8H7, RIR1_ASFK5 ;
DR   P26685, RIR1_ASFM2 ;  P0C8H8, RIR1_ASFP4 ;  P0C8H9, RIR1_ASFWA ;
DR   P50620, RIR1_BACSU ;  P50646, RIR1_BHV1C ;  P32282, RIR1_BPT4  ;
DR   P57276, RIR1_BUCAI ;  Q8K9W3, RIR1_BUCAP ;  Q89AS4, RIR1_BUCBP ;
DR   Q03604, RIR1_CAEEL ;  Q9PL93, RIR1_CHLMU ;  Q9Z6S5, RIR1_CHLPN ;
DR   O84834, RIR1_CHLTR ;  O61065, RIR1_CRYPV ;  P79732, RIR1_DANRE ;
DR   Q54Q71, RIR1_DICDI ;  P48591, RIR1_DROME ;  P0C702, RIR1_EBVA8 ;
DR   P03190, RIR1_EBVB9 ;  Q3KSU5, RIR1_EBVG  ;  P00452, RIR1_ECOLI ;
DR   P28846, RIR1_EHV1B ;  Q66663, RIR1_EHV2  ;  P50642, RIR1_EHV4  ;
DR   Q8SR37, RIR1_ENCCU ;  Q6GZT8, RIR1_FRG3G ;  Q77MS1, RIR1_GAHVM ;
DR   P43754, RIR1_HAEIN ;  Q9ZLF9, RIR1_HELPJ ;  P55982, RIR1_HELPY ;
DR   P08543, RIR1_HHV11 ;  P09853, RIR1_HHV23 ;  P89462, RIR1_HHV2H ;
DR   P23921, RIR1_HUMAN ;  Q196Z5, RIR1_IIV3  ;  O55716, RIR1_IIV6  ;
DR   Q7T6Y8, RIR1_MIMIV ;  P07742, RIR1_MOUSE ;  P0A5W9, RIR1_MYCBO ;
DR   P47473, RIR1_MYCGE ;  Q9CBQ0, RIR1_MYCLE ;  P78027, RIR1_MYCPN ;
DR   P0A5W8, RIR1_MYCTU ;  Q9UW15, RIR1_NEUCR ;  Q6R7H4, RIR1_OSHVF ;
DR   P50648, RIR1_PLAF4 ;  P50647, RIR1_PLAFG ;  Q5R919, RIR1_PONAB ;
DR   Q6UDJ2, RIR1_PSHV1 ;  P37426, RIR1_SALTY ;  P36602, RIR1_SCHPO ;
DR   Q01037, RIR1_SHV21 ;  P50643, RIR1_SUHVK ;  P74240, RIR1_SYNY3 ;
DR   O83972, RIR1_TREPA ;  O15909, RIR1_TRYBB ;  Q76RD8, RIR1_VACCA ;
DR   P20503, RIR1_VACCC ;  P12848, RIR1_VACCW ;  P32984, RIR1_VAR67 ;
DR   P09248, RIR1_VZVD  ;  Q4JQV6, RIR1_VZVO  ;  P21524, RIR1_YEAST ;
DR   P50651, RIR2A_ARATH;  Q10840, RIR2A_MYCTU;  Q6Y657, RIR2B_ARATH;
DR   Q7LG56, RIR2B_HUMAN;  Q4R741, RIR2B_MACFA;  Q6PEE3, RIR2B_MOUSE;
DR   Q50549, RIR2B_MYCTU;  Q5R9G0, RIR2B_PONAB;  Q9LSD0, RIR2C_ARATH;
DR   O36410, RIR2_ALHV1 ;  O67475, RIR2_AQUAE ;  P42492, RIR2_ASFB7 ;
DR   P0C8I0, RIR2_ASFK5 ;  P26713, RIR2_ASFM2 ;  P0C8I1, RIR2_ASFP4 ;
DR   P0C8I2, RIR2_ASFWA ;  Q9KFH7, RIR2_BACHD ;  P50621, RIR2_BACSU ;
DR   Q01319, RIR2_BHV1C ;  P11156, RIR2_BPT4  ;  P57275, RIR2_BUCAI ;
DR   Q8K9W4, RIR2_BUCAP ;  Q89AS5, RIR2_BUCBP ;  P42170, RIR2_CAEEL ;
DR   Q9PL92, RIR2_CHLMU ;  Q9Z6S4, RIR2_CHLPN ;  O84835, RIR2_CHLTR ;
DR   P79733, RIR2_DANRE ;  P42521, RIR2_DICDI ;  P48592, RIR2_DROME ;
DR   P0CAP7, RIR2_EBVA8 ;  P0CAP6, RIR2_EBVB9 ;  P0C701, RIR2_EBVG  ;
DR   P69925, RIR2_ECO57 ;  P69924, RIR2_ECOLI ;  P28847, RIR2_EHV1B ;
DR   Q66662, RIR2_EHV2  ;  P50644, RIR2_EHV4  ;  Q8SRR2, RIR2_ENCCU ;
DR   Q6GZQ8, RIR2_FRG3G ;  Q77MS0, RIR2_GAHVM ;  P43755, RIR2_HAEIN ;
DR   Q9ZKC3, RIR2_HELPJ ;  P55983, RIR2_HELPY ;  P10224, RIR2_HHV11 ;
DR   P06474, RIR2_HHV1K ;  P69520, RIR2_HHV23 ;  P69521, RIR2_HHV2H ;
DR   P31350, RIR2_HUMAN ;  Q197B2, RIR2_IIV3  ;  Q91FE8, RIR2_IIV6  ;
DR   O46310, RIR2_LEIAM ;  Q4R7Q7, RIR2_MACFA ;  Q60561, RIR2_MESAU ;
DR   Q7T6Y9, RIR2_MIMIV ;  P11157, RIR2_MOUSE ;  Q9XC20, RIR2_MYCGA ;
DR   P47471, RIR2_MYCGE ;  Q9CBQ2, RIR2_MYCLE ;  P75461, RIR2_MYCPN ;
DR   Q9C167, RIR2_NEUCR ;  Q6R7K3, RIR2_OSHVF ;  P50650, RIR2_PLAF4 ;
DR   P50649, RIR2_PLAFG ;  Q6UDJ1, RIR2_PSHV1 ;  Q4KLN6, RIR2_RAT   ;
DR   Q9QTF2, RIR2_RSIV  ;  P37427, RIR2_SALTY ;  P36603, RIR2_SCHPO ;
DR   Q01038, RIR2_SHV21 ;  P07201, RIR2_SPISO ;  P50645, RIR2_SUHVK ;
DR   P32209, RIR2_SWPVK ;  P49730, RIR2_TOBAC ;  O83092, RIR2_TREPA ;
DR   O15910, RIR2_TRYBB ;  O57175, RIR2_VACCA ;  P20493, RIR2_VACCC ;
DR   P29883, RIR2_VACCP ;  P11158, RIR2_VACCW ;  P33799, RIR2_VAR67 ;
DR   P09247, RIR2_VZVD  ;  Q4JQV7, RIR2_VZVO  ;  P09938, RIR2_YEAST ;
DR   Q9DHU2, RIR2_YLDV  ;  P39452, RIR3_ECOLI ;  Q08698, RIR3_SALTY ;
DR   P21672, RIR3_YEAST ;  P37146, RIR4_ECOLI ;  P17424, RIR4_SALTY ;
DR   P49723, RIR4_YEAST ;  O30601, YOSP_BACSU ;
//