ID   1.17.7.1
DE   (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.
AN   (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase.
AN   4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.
CA   (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized
CA   ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced
CA   ferredoxin.
CF   Iron-sulfur.
CC   -!- Forms, in the reverse direction, part of an alternative non-
CC       mevalonate pathway for isoprenoid biosynthesis that is found in most
CC       bacteria and in plant chloroplasts.
CC   -!- The enzyme from the plant Arabidopsis thaliana is active with
CC       photoreduced 5-deazaflavin but not with the flavodoxin/flavodoxin
CC       reductase/NADPH system that can be used as an electron donor by
CC       Escherichia coli.
CC   -!- Metabolites derived from isoprenoids play important roles in systems
CC       such as electron transport, photosynthesis, plant defense responses,
CC       hormonal regulation of development and membrane fluidity.
CC   -!- Formerly EC 1.17.4.3.
DR   Q82K43, ISPG1_STRAW;  Q9X7W2, ISPG1_STRCO;  Q82ML3, ISPG2_STRAW;
DR   Q9KYR9, ISPG2_STRCO;  B0C6E1, ISPG_ACAM1 ;  Q6FEM3, ISPG_ACIAD ;
DR   B7H069, ISPG_ACIB3 ;  B7I5G7, ISPG_ACIB5 ;  B2I3E5, ISPG_ACIBC ;
DR   B0VKR8, ISPG_ACIBS ;  A3M211, ISPG_ACIBT ;  B0V5G7, ISPG_ACIBY ;
DR   A0LV34, ISPG_ACIC1 ;  A5FX97, ISPG_ACICJ ;  B7JC30, ISPG_ACIF2 ;
DR   B5EJF3, ISPG_ACIF5 ;  A3N1H8, ISPG_ACTP2 ;  B3GY64, ISPG_ACTP7 ;
DR   B0BQB9, ISPG_ACTPJ ;  A6VQX6, ISPG_ACTSZ ;  B9JE02, ISPG_AGRRK ;
DR   P58665, ISPG_AGRT5 ;  B9JV07, ISPG_AGRVS ;  B2UKT9, ISPG_AKKM8 ;
DR   Q0VNE0, ISPG_ALCBS ;  B6EGY7, ISPG_ALISL ;  B4RV89, ISPG_ALTMD ;
DR   Q5PAJ1, ISPG_ANAMM ;  Q3MG27, ISPG_ANAVT ;  B7GH89, ISPG_ANOFW ;
DR   O67496, ISPG_AQUAE ;  Q5P7B3, ISPG_AROAE ;  A1R501, ISPG_ARTAT ;
DR   B8HG44, ISPG_ARTCA ;  A0JUS8, ISPG_ARTS2 ;  C1DE57, ISPG_AZOVD ;
DR   A7Z6S2, ISPG_BACA2 ;  C3P8I5, ISPG_BACAA ;  C3LKV7, ISPG_BACAC ;
DR   A0RIQ2, ISPG_BACAH ;  Q81LV7, ISPG_BACAN ;  B7JN03, ISPG_BACC0 ;
DR   Q730Q8, ISPG_BACC1 ;  B7IYD0, ISPG_BACC2 ;  C1ES01, ISPG_BACC3 ;
DR   B7HCQ3, ISPG_BACC4 ;  B7HPH8, ISPG_BACC7 ;  A7GSX5, ISPG_BACCN ;
DR   B9IY45, ISPG_BACCQ ;  Q818H8, ISPG_BACCR ;  Q634Q9, ISPG_BACCZ ;
DR   Q5L7W2, ISPG_BACFN ;  Q64N34, ISPG_BACFR ;  Q9KD18, ISPG_BACHD ;
DR   Q6HDN9, ISPG_BACHK ;  Q65HA9, ISPG_BACLD ;  A8FF87, ISPG_BACP2 ;
DR   Q5WHB2, ISPG_BACSK ;  P54482, ISPG_BACSU ;  Q8A4T0, ISPG_BACTN ;
DR   A6L089, ISPG_BACV8 ;  A9VH61, ISPG_BACWK ;  A1UR54, ISPG_BARBK ;
DR   Q6G1X4, ISPG_BARHE ;  Q6G104, ISPG_BARQU ;  A9IYW1, ISPG_BART1 ;
DR   Q1LU77, ISPG_BAUCH ;  B2IE63, ISPG_BEII9 ;  Q8G7Y6, ISPG_BIFLO ;
DR   Q492E0, ISPG_BLOPB ;  Q7WHN0, ISPG_BORBR ;  Q7W6P6, ISPG_BORPA ;
DR   Q7VWL0, ISPG_BORPE ;  Q89VV9, ISPG_BRAJA ;  A5ETI5, ISPG_BRASB ;
DR   A4YKQ8, ISPG_BRASO ;  C0ZF58, ISPG_BREBN ;  B2S7K6, ISPG_BRUA1 ;
DR   Q2YLG4, ISPG_BRUA2 ;  Q57BA5, ISPG_BRUAB ;  A9M820, ISPG_BRUC2 ;
DR   C0RF32, ISPG_BRUMB ;  Q8YJ17, ISPG_BRUME ;  A9WWQ2, ISPG_BRUSI ;
DR   Q8FYT2, ISPG_BRUSU ;  P57374, ISPG_BUCAI ;  Q8K9P4, ISPG_BUCAP ;
DR   B1YR44, ISPG_BURA4 ;  B4EAW9, ISPG_BURCJ ;  A3MK75, ISPG_BURM7 ;
DR   A2S2A2, ISPG_BURM9 ;  Q62JW4, ISPG_BURMA ;  A1V4K1, ISPG_BURMS ;
DR   A3NVX1, ISPG_BURP0 ;  Q3JRQ3, ISPG_BURP1 ;  A3NA54, ISPG_BURP6 ;
DR   Q63UT3, ISPG_BURPS ;  A4XLZ4, ISPG_CALS8 ;  A7ZCT9, ISPG_CAMC1 ;
DR   A7GZ54, ISPG_CAMC5 ;  A0RPL8, ISPG_CAMFF ;  A8FLB6, ISPG_CAMJ8 ;
DR   A7H4D8, ISPG_CAMJD ;  Q9PPM1, ISPG_CAMJE ;  A1VZ41, ISPG_CAMJJ ;
DR   Q5HV95, ISPG_CAMJR ;  B9KD64, ISPG_CAMLR ;  Q9A9W0, ISPG_CAUCR ;
DR   B3PDM1, ISPG_CELJU ;  Q5L669, ISPG_CHLAB ;  Q823I7, ISPG_CHLCV ;
DR   Q254D2, ISPG_CHLFF ;  Q9PKY3, ISPG_CHLMU ;  Q9Z8H0, ISPG_CHLPN ;
DR   B0B9G5, ISPG_CHLT2 ;  Q3KMW4, ISPG_CHLTA ;  B0BB44, ISPG_CHLTB ;
DR   Q8KG23, ISPG_CHLTE ;  O84060, ISPG_CHLTR ;  Q1QTK8, ISPG_CHRSD ;
DR   Q7NS88, ISPG_CHRVO ;  A8AD71, ISPG_CITK8 ;  A5CT01, ISPG_CLAM3 ;
DR   B0RDZ5, ISPG_CLAMS ;  Q97I56, ISPG_CLOAB ;  B8I6E1, ISPG_CLOCE ;
DR   P58667, ISPG_CLOPE ;  Q895K3, ISPG_CLOTE ;  Q47WC0, ISPG_COLP3 ;
DR   Q6NGL3, ISPG_CORDI ;  Q8FP82, ISPG_COREF ;  Q8NP12, ISPG_CORGL ;
DR   Q4JV28, ISPG_CORJK ;  B1VGA4, ISPG_CORU7 ;  A7MGV7, ISPG_CROS8 ;
DR   B1WQF1, ISPG_CYAA5 ;  B8HSI6, ISPG_CYAP4 ;  B7KJJ4, ISPG_CYAP7 ;
DR   B7K5R5, ISPG_CYAP8 ;  Q47BR6, ISPG_DECAR ;  A5FS85, ISPG_DEHSB ;
DR   Q3ZZC9, ISPG_DEHSC ;  Q9RXC9, ISPG_DEIRA ;  C6BYK9, ISPG_DESAD ;
DR   Q6AP32, ISPG_DESPS ;  Q72CD9, ISPG_DESVH ;  A8LI72, ISPG_DINSH ;
DR   A7ZPV8, ISPG_ECO24 ;  B7UGW1, ISPG_ECO27 ;  B7MI00, ISPG_ECO45 ;
DR   B7LDA7, ISPG_ECO55 ;  P62622, ISPG_ECO57 ;  B5Z0Y4, ISPG_ECO5E ;
DR   B7NRG5, ISPG_ECO7I ;  B7MYF0, ISPG_ECO81 ;  B7M7L9, ISPG_ECO8A ;
DR   C4ZX90, ISPG_ECOBW ;  B1XAZ0, ISPG_ECODH ;  A8A321, ISPG_ECOHS ;
DR   A1AE53, ISPG_ECOK1 ;  Q0TEX0, ISPG_ECOL5 ;  P62621, ISPG_ECOL6 ;
DR   B1IWE6, ISPG_ECOLC ;  P62620, ISPG_ECOLI ;  B7N6A3, ISPG_ECOLU ;
DR   B6I587, ISPG_ECOSE ;  B1LNH0, ISPG_ECOSM ;  Q1R8L8, ISPG_ECOUT ;
DR   Q3YRZ7, ISPG_EHRCJ ;  Q5FHA6, ISPG_EHRRG ;  Q5HB57, ISPG_EHRRW ;
DR   A4WD93, ISPG_ENT38 ;  Q6D276, ISPG_ERWCT ;  B2VE89, ISPG_ERWT9 ;
DR   B7LKC3, ISPG_ESCF3 ;  B1YLA2, ISPG_EXIS2 ;  C4L3K5, ISPG_EXISA ;
DR   Q0RDR2, ISPG_FRAAA ;  Q2J717, ISPG_FRASC ;  A8L6E2, ISPG_FRASN ;
DR   Q14IL6, ISPG_FRAT1 ;  B2SG03, ISPG_FRATM ;  A0Q6U8, ISPG_FRATN ;
DR   Q0BMA6, ISPG_FRATO ;  Q5NH64, ISPG_FRATT ;  Q8RG40, ISPG_FUSNN ;
DR   Q5KX35, ISPG_GEOKA ;  Q74D60, ISPG_GEOSL ;  C5D4Q3, ISPG_GEOSW ;
DR   A4IQZ4, ISPG_GEOTN ;  Q7NFA4, ISPG_GLOVI ;  A9HJ48, ISPG_GLUDA ;
DR   Q5FUR7, ISPG_GLUOX ;  Q0BUK0, ISPG_GRABC ;  Q7VME2, ISPG_HAEDU ;
DR   Q4QNH4, ISPG_HAEI8 ;  A5UAB9, ISPG_HAEIE ;  A5UGH1, ISPG_HAEIG ;
DR   P44667, ISPG_HAEIN ;  Q0I2E9, ISPG_HAES1 ;  B0USG8, ISPG_HAES2 ;
DR   Q2SDW4, ISPG_HAHCH ;  C4K4I8, ISPG_HAMD5 ;  Q17XU2, ISPG_HELAH ;
DR   Q7VI04, ISPG_HELHP ;  B6JLL3, ISPG_HELP2 ;  B5Z6Z7, ISPG_HELPG ;
DR   Q1CTP7, ISPG_HELPH ;  Q9ZLL0, ISPG_HELPJ ;  B2UTK0, ISPG_HELPS ;
DR   O25342, ISPG_HELPY ;  B4U9V3, ISPG_HYDS0 ;  Q0C4J3, ISPG_HYPNA ;
DR   Q5QYA9, ISPG_IDILO ;  Q28R10, ISPG_JANSC ;  B5XNL5, ISPG_KLEP3 ;
DR   A6TCD4, ISPG_KLEP7 ;  B2GKS3, ISPG_KOCRD ;  Q1IRS5, ISPG_KORVE ;
DR   C1DD43, ISPG_LARHH ;  Q1MSE5, ISPG_LAWIP ;  Q6AEX9, ISPG_LEIXX ;
DR   Q04UL2, ISPG_LEPBJ ;  Q04YW2, ISPG_LEPBL ;  Q72TR2, ISPG_LEPIC ;
DR   Q8F1H5, ISPG_LEPIN ;  C1L2Z7, ISPG_LISMC ;  Q71ZM9, ISPG_LISMF ;
DR   P58668, ISPG_LISMO ;  B1HSS4, ISPG_LYSSC ;  B9E6U1, ISPG_MACCJ ;
DR   A0LDN3, ISPG_MAGSM ;  Q65R84, ISPG_MANSM ;  A1TZQ0, ISPG_MARAV ;
DR   A6VV06, ISPG_MARMS ;  Q604Q5, ISPG_METCA ;  Q1H0U9, ISPG_METFK ;
DR   B0JJJ8, ISPG_MICAN ;  Q7TXN6, ISPG_MYCBO ;  A1KML3, ISPG_MYCBP ;
DR   C1AFY4, ISPG_MYCBT ;  Q7NBH3, ISPG_MYCGA ;  B8ZRU5, ISPG_MYCLB ;
DR   Q9CBU5, ISPG_MYCLE ;  Q73VS3, ISPG_MYCPA ;  Q8EUI6, ISPG_MYCPE ;
DR   A5U6M2, ISPG_MYCTA ;  O33350, ISPG_MYCTU ;  B2A390, ISPG_NATTJ ;
DR   B9LA27, ISPG_NAUPA ;  Q5F913, ISPG_NEIG1 ;  B4RMG4, ISPG_NEIG2 ;
DR   A9LZN8, ISPG_NEIM0 ;  Q9JU34, ISPG_NEIMA ;  Q9JZ40, ISPG_NEIMB ;
DR   A1KUD8, ISPG_NEIMF ;  Q0AE42, ISPG_NITEC ;  Q82XV0, ISPG_NITEU ;
DR   Q1QQI9, ISPG_NITHX ;  A6Q1U2, ISPG_NITSB ;  Q3SVD0, ISPG_NITWN ;
DR   Q5YS74, ISPG_NOCFA ;  B2J1G1, ISPG_NOSP7 ;  P58666, ISPG_NOSS1 ;
DR   A6WXY9, ISPG_OCHA4 ;  B6JA27, ISPG_OLICO ;  A6LGR5, ISPG_PARD8 ;
DR   A1B323, ISPG_PARDP ;  Q6MD85, ISPG_PARUW ;  P57987, ISPG_PASMU ;
DR   C6DBH4, ISPG_PECCP ;  Q4FNA0, ISPG_PELUB ;  C0QRI5, ISPG_PERMH ;
DR   Q7N706, ISPG_PHOLL ;  Q6LU49, ISPG_PHOPR ;  Q7MVT7, ISPG_PORGI ;
DR   Q6A7L2, ISPG_PROAC ;  Q7VBS7, ISPG_PROMA ;  B4EZT3, ISPG_PROMH ;
DR   Q7V7G9, ISPG_PROMM ;  Q7V215, ISPG_PROMP ;  P72241, ISPG_PROST ;
DR   Q48LZ4, ISPG_PSE14 ;  A6V0W0, ISPG_PSEA7 ;  B7UWI8, ISPG_PSEA8 ;
DR   Q02RV7, ISPG_PSEAB ;  Q9HXJ4, ISPG_PSEAE ;  Q1IEI1, ISPG_PSEE4 ;
DR   Q4K6U9, ISPG_PSEF5 ;  C3K1L4, ISPG_PSEFS ;  Q3ICZ5, ISPG_PSEHT ;
DR   A4XY32, ISPG_PSEMY ;  A5VYT5, ISPG_PSEP1 ;  Q3K7B6, ISPG_PSEPF ;
DR   B0KPI7, ISPG_PSEPG ;  Q88PJ7, ISPG_PSEPK ;  B1JDV8, ISPG_PSEPW ;
DR   Q886Z0, ISPG_PSESM ;  Q4ZX23, ISPG_PSEU2 ;  Q4FTW7, ISPG_PSYA2 ;
DR   Q1QD18, ISPG_PSYCK ;  A1SU39, ISPG_PSYIN ;  B2U9U9, ISPG_RALPJ ;
DR   P58669, ISPG_RALSO ;  A9WR14, ISPG_RENSM ;  B3PR71, ISPG_RHIE6 ;
DR   Q2K333, ISPG_RHIEC ;  Q1MAC5, ISPG_RHIL3 ;  Q98FG0, ISPG_RHILO ;
DR   B5ZUA0, ISPG_RHILW ;  Q92L19, ISPG_RHIME ;  C3MAL6, ISPG_RHISN ;
DR   Q7UWC8, ISPG_RHOBA ;  C1B2V4, ISPG_RHOOB ;  Q2J2S7, ISPG_RHOP2 ;
DR   Q07V91, ISPG_RHOP5 ;  Q6NCF3, ISPG_RHOPA ;  Q21C20, ISPG_RHOPB ;
DR   B3QBC6, ISPG_RHOPT ;  Q2RWE4, ISPG_RHORT ;  A1AW46, ISPG_RUTMC ;
DR   Q21KT3, ISPG_SACD2 ;  B5F198, ISPG_SALA4 ;  A8M723, ISPG_SALAI ;
DR   A9MHL5, ISPG_SALAR ;  Q57LI6, ISPG_SALCH ;  B5FR63, ISPG_SALDC ;
DR   B5R582, ISPG_SALEP ;  B5RCZ2, ISPG_SALG2 ;  B4TD93, ISPG_SALHS ;
DR   B4T0P9, ISPG_SALNS ;  Q5PNI2, ISPG_SALPA ;  A9N201, ISPG_SALPB ;
DR   B5BAY5, ISPG_SALPK ;  B4TR95, ISPG_SALSV ;  P58670, ISPG_SALTI ;
DR   A4X4L9, ISPG_SALTO ;  P58671, ISPG_SALTY ;  A8GHW5, ISPG_SERP5 ;
DR   A1S863, ISPG_SHEAM ;  B8E9S7, ISPG_SHEB2 ;  A3D6V9, ISPG_SHEB5 ;
DR   A6WQP7, ISPG_SHEB8 ;  A9KXK8, ISPG_SHEB9 ;  Q12PT4, ISPG_SHEDO ;
DR   Q085U6, ISPG_SHEFN ;  B0TLI4, ISPG_SHEHH ;  A3QCG2, ISPG_SHELP ;
DR   Q8EC32, ISPG_SHEON ;  A8H245, ISPG_SHEPA ;  A4Y8U0, ISPG_SHEPC ;
DR   B8CKR1, ISPG_SHEPW ;  A0KUJ5, ISPG_SHESA ;  A8FT70, ISPG_SHESH ;
DR   Q0HKV9, ISPG_SHESM ;  Q0HX57, ISPG_SHESR ;  A1RHQ3, ISPG_SHESW ;
DR   B1KKJ2, ISPG_SHEWM ;  B2TXU0, ISPG_SHIB3 ;  Q31XX5, ISPG_SHIBS ;
DR   Q32D47, ISPG_SHIDS ;  Q0T204, ISPG_SHIF8 ;  Q83K43, ISPG_SHIFL ;
DR   Q3YZ37, ISPG_SHISS ;  Q5LQ99, ISPG_SILPO ;  Q1GIC1, ISPG_SILST ;
DR   A6UE79, ISPG_SINMW ;  Q2NS40, ISPG_SODGM ;  Q029T9, ISPG_SOLUE ;
DR   B1VYP5, ISPG_STRGG ;  B4SRZ0, ISPG_STRM5 ;  B2FL74, ISPG_STRMK ;
DR   Q30TM4, ISPG_SULDN ;  A6QC65, ISPG_SULNB ;  B2V7Y2, ISPG_SULSY ;
DR   Q67PA7, ISPG_SYMTH ;  Q31QC4, ISPG_SYNE7 ;  Q2JS69, ISPG_SYNJA ;
DR   Q2JPZ9, ISPG_SYNJB ;  B1XHZ7, ISPG_SYNP2 ;  Q5N3W3, ISPG_SYNP6 ;
DR   Q7U712, ISPG_SYNPX ;  Q0I9J4, ISPG_SYNS3 ;  Q3AXP3, ISPG_SYNS9 ;
DR   Q3AK30, ISPG_SYNSC ;  P73672, ISPG_SYNY3 ;  B7IFY1, ISPG_THEAB ;
DR   Q8DK70, ISPG_THEEB ;  Q47RY0, ISPG_THEFY ;  A8F4Y8, ISPG_THELT ;
DR   Q9WZZ3, ISPG_THEMA ;  A5IIP2, ISPG_THEP1 ;  B1LC43, ISPG_THESQ ;
DR   Q72H18, ISPG_THET2 ;  Q5SLI8, ISPG_THET8 ;  Q84GJ3, ISPG_THETH ;
DR   Q8RA30, ISPG_THETN ;  B5YIQ4, ISPG_THEYD ;  Q73N90, ISPG_TREDE ;
DR   O83460, ISPG_TREPA ;  Q10W70, ISPG_TRIEI ;  Q83NE4, ISPG_TROW8 ;
DR   Q83N18, ISPG_TROWT ;  A5CX35, ISPG_VESOH ;  Q9KTX1, ISPG_VIBCH ;
DR   Q5E772, ISPG_VIBF1 ;  B5FAX2, ISPG_VIBFM ;  A7MU42, ISPG_VIBHB ;
DR   Q87S16, ISPG_VIBPA ;  B7VJT8, ISPG_VIBSL ;  Q8DEZ8, ISPG_VIBVU ;
DR   Q7MNF1, ISPG_VIBVY ;  Q8D1Y3, ISPG_WIGBR ;  Q73IP1, ISPG_WOLPM ;
DR   B3CNN4, ISPG_WOLPP ;  Q7M8Z2, ISPG_WOLSU ;  Q5GRK4, ISPG_WOLTR ;
DR   C0R5E5, ISPG_WOLWR ;  Q8PLJ8, ISPG_XANAC ;  Q3BUK3, ISPG_XANC5 ;
DR   Q4UTW8, ISPG_XANC8 ;  B0RTS9, ISPG_XANCB ;  Q8P9R7, ISPG_XANCP ;
DR   Q2P3M7, ISPG_XANOM ;  Q5H0N8, ISPG_XANOR ;  Q9PAE3, ISPG_XYLFA ;
DR   Q87A73, ISPG_XYLFT ;  A1JKS2, ISPG_YERE8 ;  A7FFY9, ISPG_YERP3 ;
DR   Q1C5I8, ISPG_YERPA ;  B2K9Q0, ISPG_YERPB ;  P58672, ISPG_YERPE ;
DR   A9R802, ISPG_YERPG ;  Q1CK91, ISPG_YERPN ;  A4TMT7, ISPG_YERPP ;
DR   Q667Z9, ISPG_YERPS ;  B1JS05, ISPG_YERPY ;  Q5NR50, ISPG_ZYMMO ;
//