ENZYME entry: EC 18.104.22.168
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|Bile acid 7-dehydroxylase.|
- Deoxycholate + FAD + H(2)O <=> cholate + FADH(2)
- Lithocholate + FAD + H(2)O <=> chenodeoxycholate + FADH(2)
- Under physiological conditions, the reactions form deoxycholate.
- This enzyme is highly specific for bile-acid substrates and requires
a free C-24 carboxy group and an unhindered 7-alpha-hydroxy group on
the B-ring of the steroid nucleus for activity, as found in cholate
- The reaction is stimulated by the presence of NAD(+) but is inhibited
by excess NADH.
- This unusual regulation by the NAD(+)/NADH ratio is most likely the
result of the intermediates being linked at C-24 by an anhydride bond
to the 5'-diphosphate of 3'-phospho-ADP.
- Allodeoxycholate is also formed as a side-product of the 7-alpha-
dehydroxylation of cholate.
- The enzyme is present in intestinal anaerobic bacteria, even though
its products are important in mammalian physiology.
- Formerly EC 22.214.171.124 and EC 126.96.36.199.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
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