ENZYME entry: EC

Accepted Name
Bile-acid 7-alpha-dehydroxylase.
Alternative Name(s)
Bile acid 7-dehydroxylase.
Cholate 7-alpha-dehydroxylase.
Reaction catalysed
  • Deoxycholate + FAD + H(2)O <=> cholate + FADH(2)
  • Lithocholate + FAD + H(2)O <=> chenodeoxycholate + FADH(2)
  • Under physiological conditions, the reactions form deoxycholate.
  • This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7-alpha-hydroxy group on the B-ring of the steroid nucleus for activity, as found in cholate and chenodeoxycholate.
  • The reaction is stimulated by the presence of NAD(+) but is inhibited by excess NADH.
  • This unusual regulation by the NAD(+)/NADH ratio is most likely the result of the intermediates being linked at C-24 by an anhydride bond to the 5'-diphosphate of 3'-phospho-ADP.
  • Allodeoxycholate is also formed as a side-product of the 7-alpha- dehydroxylation of cholate.
  • The enzyme is present in intestinal anaerobic bacteria, even though its products are important in mammalian physiology.
  • Formerly EC and EC
PRIAM enzyme-specific profiles1.17.98.1
KEGG Ligand Database for Enzyme Nomenclature1.17.98.1
IUBMB Enzyme Nomenclature1.17.98.1
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.98.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-