ENZYME entry: EC 1.17.99.1

Accepted Name
4-methylphenol dehydrogenase (hydroxylating).
Alternative Name(s)
4-cresol dehydrogenase (hydroxylating).
p-cresol methylhydroxylase.
p-cresol-(acceptor) oxidoreductase (hydroxylating).
Reaction catalysed
4-methylphenol + 2 acceptor + H(2)O <=> 4-hydroxybenzaldehyde + 2 reduced acceptor
Cofactor(s)
FAD.
Comment(s)
  • Phenazine methosulfate can act as acceptor.
  • A quinone methide is probably formed as intermediate.
  • The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde.
Cross-references
BRENDA1.17.99.1
EC2PDB1.17.99.1
ExplorEnz1.17.99.1
PRIAM enzyme-specific profiles1.17.99.1
KEGG Ligand Database for Enzyme Nomenclature1.17.99.1
IUBMB Enzyme Nomenclature1.17.99.1
IntEnz1.17.99.1
MEDLINEFind literature relating to 1.17.99.1
MetaCyc1.17.99.1
UniProtKB/Swiss-Prot
P09788, DH4C_PSEPU

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